ArticleThe Journal of general virology2005
Dengue virus-induced apoptosis in hepatic cells is partly mediated by Apo2 ligand/tumour necrosis factor-related apoptosis-inducing ligand.
Article in The Journal of general virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 57 citations in OpenAlex.
- Immunomodulation in dengue: towards deciphering dengue severity markers.Cell communication and signaling : CCS · 2024Review
- Review
- Immune-Mediated Pathogenesis in Dengue Virus Infection.Viruses · 2022Review
- Apoptosis characterization in mononuclear blood leukocytes of HIV patients during dengue acute disease.Scientific reports · 2020Article
- Soluble Fas Ligand as a Potential Marker of Severity of Dengue Infection.The Malaysian journal of medical sciences : MJMS · 2017Article
- Dengue Virus Induces NK Cell Activation through TRAIL Expression during Infection.Mediators of inflammation · 2017Article
- SB203580 Modulates p38 MAPK Signaling and Dengue Virus-Induced Liver Injury by Reducing MAPKAPK2, HSP27, and ATF2 Phosphorylation.PloS one · 2016Article
- Dengue and its effects on liver.World journal of clinical cases · 2015Review
- Apoptotic mediators in patients with severe and non-severe dengue from Brazil.Journal of medical virology · 2014Article
- Dengue pathogenesis: a disease driven by the host response.Science progress · 2014Review
- Dengue 2 infection of HepG2 liver cells results in endoplasmic reticulum stress and induction of multiple pathways of cell death.BMC research notes · 2013Article
- Inhibition of p38MAPK and CD137 signaling reduce dengue virus-induced TNF-α secretion and apoptosis.Virology journal · 2013Article
- The battle between infection and host immune responses of dengue virus and its implication in dengue disease pathogenesis.TheScientificWorldJournal · 2013Review
- Intrahepatic infiltrating NK and CD8 T cells cause liver cell death in different phases of dengue virus infection.PloS one · 2012Article
- Comparative evaluation of permissiveness to dengue virus serotype 2 infection in primary rodent macrophages.Journal of tropical medicine · 2012Article
- Crimean-Congo hemorrhagic fever virus-infected hepatocytes induce ER-stress and apoptosis crosstalk.PloS one · 2012Article
- Liv.52 regulates ethanol induced PPARgamma and TNF alpha expression in HepG2 cells.Molecular and cellular biochemistry · 2008Article
- Independent and cooperative antiviral actions of beta interferon and gamma interferon against herpes simplex virus replication in primary human fibroblasts.Journal of virology · 2008Article
- TRAIL is a novel antiviral protein against dengue virus.Journal of virology · 2008Article
- Host gene expression profiling of dengue virus infection in cell lines and patients.PLoS neglected tropical diseases · 2007Article
Corrections and comments
- Retraction · 2010-01-10Duplication of/in Image ·
- Retracted
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Although hepatic injury is reported in cases with dengue haemorrhagic fever and dengue shock syndrome, its mechanism remains poorly understood. Several findings suggest that dengue virus (DEN) induces apoptosis of hepatocytes in vivo. In this work, DEN type 2 (DEN-2) strain NGC was shown to induce apoptosis in the hepatic cell line HepG2, and infection of HepG2 cells was found to induce Apo2 ligand (Apo2L, also known as tumour necrosis factor-related apoptosis-inducing ligand or TRAIL) expression. Furthermore, Apo2L/TRAIL induced apoptosis in HepG2 cells, which expressed the Apo2L/TRAIL receptor DR5/TRAIL-R2 on their surface. Analysis of the Apo2L/TRAIL promoter revealed that this gene was activated by DEN-2 infection, whose responsive element was overlapping NF-kappaB- and Sp1-binding sites located at nt -75 to -65. The proteasome inhibitor N-acetyl-L-leucinyl-L-leucinyl-L-norleucinal (LLnL) inhibited Apo2L/TRAIL mRNA expression, and LLnL and anti-Apo2L/TRAIL antibody inhibited DEN-2-induced apoptosis. It was proposed that DEN infection promotes apoptosis partly through the induction of Apo2L/TRAIL expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.