ArticleInfection and immunity2005
Leishmania major modulates chemokine and chemokine receptor expression by dendritic cells and affects their migratory capacity.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Lipid Mediators in Host-Pathogen Interactions duringACS infectious diseases · 2026Review
- Advances inPathogens (Basel, Switzerland) · 2024Review
- The cytokine/chemokine response inHeliyon · 2023Review
- Article
- Review
- Molecular Aspects of Dendritic Cell Activation in Leishmaniasis: An Immunobiological View.Frontiers in immunology · 2019Review
- The site of the bite: Leishmania interaction with macrophages, neutrophils and the extracellular matrix in the dermis.Parasites & vectors · 2016Review
- Leishmania infection modulates beta-1 integrin activation and alters the kinetics of monocyte spreading over fibronectin.Scientific reports · 2015Article
- Immunosuppressive effects of Amblyomma cajennense tick saliva on murine bone marrow-derived dendritic cells.Parasites & vectors · 2015Article
- Leishmania amazonensis infection impairs dendritic cell migration from the inflammatory site to the draining lymph node.BMC infectious diseases · 2014Article
- Deficiency of lymph node-resident dendritic cells (DCs) and dysregulation of DC chemoattractants in a malnourished mouse model of Leishmania donovani infection.Infection and immunity · 2014Article
- Improvement of the efficacy of dihydroartemisinin with atorvastatin in an experimental cerebral malaria murine model.Malaria journal · 2013Article
- Chemokines and chemokine receptors expression in the lesions of patients with American cutaneous leishmaniasis.Memorias do Instituto Oswaldo Cruz · 2013Article
- Lymph node hypertrophy following Leishmania major infection is dependent on TLR9.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Role of chemokines in regulation of immunity against leishmaniasis.Experimental parasitology · 2010Review
- B7-H1 blockade increases survival of dysfunctional CD8(+) T cells and confers protection against Leishmania donovani infections.PLoS pathogens · 2009Article
- Modulation of dendritic cell function by Leishmania parasites.Journal of immunology (Baltimore, Md. : 1950) · 2008Review
- Effects of CXCL10 on dendritic cell and CD4+ T-cell functions during Leishmania amazonensis infection.Infection and immunity · 2008Article
- Genetic profiling of dendritic cells exposed to live- or ultraviolet-irradiated Chlamydia muridarum reveals marked differences in CXC chemokine profiles.Immunology · 2007Article
- CXCL10/gamma interferon-inducible protein 10-mediated protection against Leishmania amazonensis infection in mice.Infection and immunity · 2006Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dendritic cells (DC) both produce and respond to chemokines. We examined the profiles of chemokines and chemokine receptors expressed by DC and their chemotactic response after interaction with Leishmania major. Expression of the chemokine receptors CCR2 and CCR5 by DC and their responsiveness to the respective ligands, CCL2 and CCL3, were downregulated, while the level of CCR7 and the DC response to its ligand CCL21 were enhanced. These parasite-induced alterations were observed with DC from L. major-resistant and -susceptible mice. In contrast, expression of the chemokine CXCL10 was elicited only in DC from L. major-resistant mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.