ArticleInfection and immunity2005
Potential role of the chemokine macrophage inflammatory protein 1alpha in human and experimental schistosomiasis.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Schistosomiasis Mansoni-Recruited Eosinophils: An Overview in the Granuloma Context.Microorganisms · 2022Review
- Transient Ascaris suum larval migration induces intractable chronic pulmonary disease and anemia in mice.PLoS neglected tropical diseases · 2021Article
- Granuloma formation and tissue pathology in Schistosoma japonicum versus Schistosoma mansoni infections.Parasite immunology · 2021Review
- Previous History of American Tegumentary Leishmaniasis Alters Susceptibility and Immune Response AgainstFrontiers in immunology · 2021Article
- NLRP6 Plays an Important Role in Early Hepatic Immunopathology Caused byFrontiers in immunology · 2020Article
- Schistosoma mansoni PCRClinical and experimental immunology · 2019Article
- Host Regulators of Liver Fibrosis During Human Schistosomiasis.Frontiers in immunology · 2018Review
- Taurine drinking ameliorates hepatic granuloma and fibrosis in mice infected with Schistosoma japonicum.International journal for parasitology. Drugs and drug resistance · 2016Article
- Article
- Role of Chemokines and Trafficking of Immune Cells in Parasitic Infections.Current immunology reviews · 2013Article
- Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosoma mansoni Infection.Journal of parasitology research · 2012Article
- Levels of certain tumor markers as differential factors between bilharzial and non-biharzial bladder cancer among Egyptian patients.Cancer cell international · 2011Article
- Experimental infection with Schistosoma mansoni in CCR5-deficient mice is associated with increased disease severity, as CCR5 plays a role in controlling granulomatous inflammation.Infection and immunity · 2011Article
- Downregulation of MIP-1alpha/CCL3 with praziquantel treatment in Schistosoma haematobium and HIV-1 co-infected individuals in a rural community in Zimbabwe.BMC infectious diseases · 2009Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In human schistosomiasis, the concentrations of the chemokine macrophage inflammatory protein 1alpha (MIP-1alpha/CCL3) is greater in the plasma of patients with clinical hepatosplenic disease. The objective of the present study was to confirm the ability of CCL3 to detect severe disease in patients classified by ultrasonography (US) and to evaluate the potential role of CCL3 in Schistosoma mansoni-infected mice. CCL3 was measured by enzyme-linked immunosorbent assay in the plasma of S. mansoni-infected patients. CCL3-deficient mice were infected with 25 cercariae, and various inflammatory and infectious indices were evaluated. The concentration of CCL3 was higher in the plasma of S. mansoni-infected than noninfected patients. Moreover, CCL3 was greater in those with US-defined hepatosplenic than with the intestinal form of the disease. In CCL3-deficient mice, the size of the granuloma and the liver eosinophil peroxidase activity and collagen content were diminished compared to wild-type mice. In CCL3-deficient mice, the worm burden after 14 weeks of infection, but not after 9 weeks, was consistently smaller. The in vitro response of mesenteric lymph node cells to antigen stimulation was characterized by lower levels of interleukin-4 (IL-4) and IL-10. CCL3 is a marker of disease severity in infected humans, and experimental studies in mice suggest that CCL3 may be a causative factor in the development of severe schistosomiasis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.