ArticleInfection and immunity2005
Q fever pneumonia: virulence of Coxiella burnetii pathovars in a murine model of aerosol infection.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed.
- Bioluminescent imaging to investigateInfection and immunity · 2025Article
- Exposure of feral swine toFrontiers in epidemiology · 2025Article
- Serosurveillance ofJournal of clinical microbiology · 2024Article
- Navigating Q fever: Current perspectives and challenges in outbreak preparedness.Open veterinary journal · 2024Review
- Tracking the Source of Human Q Fever from a Southern French Village: Sentinel Animals and Environmental Reservoir.Microorganisms · 2023Article
- A Survey of Two-Component Systems in Coxiella burnetii Reveals Redundant Regulatory Schemes and a Requirement for an Atypical PhoBR System in Mammalian Cell Infection.Journal of bacteriology · 2023Article
- The endogenous Coxiella burnetii plasmid encodes a functional toxin-antitoxin system.Molecular microbiology · 2022Article
- Role of Goats in the Epidemiology ofBiology · 2022Review
- Metabolic Plasticity Aids Amphotropism of Coxiella burnetii.Infection and immunity · 2021Article
- FromPathogens (Basel, Switzerland) · 2021Review
- Quantitative Microbial Risk Assessment for Airborne Transmission of SARS-CoV-2 via Breathing, Speaking, Singing, Coughing, and Sneezing.Environmental health perspectives · 2021Article
- The anti-apoptotic Coxiella burnetii effector protein AnkG is a strain specific virulence factor.Scientific reports · 2020Article
- Transmission ofEpidemiology and infection · 2020Article
- T-Bet Controls Susceptibility of Mice toFrontiers in microbiology · 2020Article
- Dependency ofJournal of bacteriology · 2019Article
- Evaluation of the Possibility ofJournal of veterinary research · 2019Article
- Extensive genome analysis of Coxiella burnetii reveals limited evolution within genomic groups.BMC genomics · 2019Article
- Article
- Coxiella burnetii Blocks Intracellular Interleukin-17 Signaling in Macrophages.Infection and immunity · 2018Article
- Draft Genome Sequences of ThreeGenome announcements · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Q fever is a worldwide zoonosis caused by Coxiella burnetii, a strictly intracellular bacterium that is a potential bioweapon. Humans usually acquires Q fever after inhalation of dust infected by subclinical animals. We used an aerosol exposure apparatus to challenge immunocompetent (BALB/c) and severe combined immunodeficient (SCID) mice with two different strains (strain Nine Mile and strain Q 212) of C. burnetii at two different inocula. Pathological lesions and dissemination of the bacteria were related to the size of the inoculum. SCID mice showed major pulmonary lesions, whereas similarly infected BALB/c mice were more able to eliminate the bacteria. Pathological differences were found between the strains, with Nine Mile showing more severe histological lesions and quantified spread of bacteria. Our animal model could provide a new tool for the study of acute Q fever pneumonia, the development of Q fever in immunodeficient hosts, and the differentiation of pathogenicity among C. burnetii isolates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.