ArticleInfection and immunity2005
Identification and functional characterization of chicken toll-like receptor 5 reveals a fundamental role in the biology of infection with Salmonella enterica serovar typhimurium.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
59 citing papers in PubMed.
- The role of cyclooxygenase-2 in oxidative stress and inflammation: Implications for poultry health and production.Poultry science · 2026Review
- The impact of innate and humoral immune mechanisms on vaccine induced protection against avian influenza H9N2 in broilers.Scientific reports · 2025Article
- 16S rRNA Sequencing and Metabolomics to Analyze Correlation Between Fecal Flora and Metabolites of Squabs and Parent Pigeons.Animals : an open access journal from MDPI · 2025Article
- Probiotic Mixtures Consisting of Representatives of Bacteroidetes and Selenomonadales Increase Resistance of Newly Hatched Chicks toMicroorganisms · 2024Article
- Review
- Disentangling the innate immune responses of intestinal epithelial cells and lamina propria cells toFrontiers in microbiology · 2023Article
- Necrotic Enteritis in Broiler Chickens: A Review on the Pathogen, Pathogenesis, and Prevention.Microorganisms · 2022Review
- Characterization of the cecal microbiome composition of Nigerian indigenous chickens.Tropical animal health and production · 2022Article
- Evolution of RNA sensing receptors in birds.Immunogenetics · 2022Review
- Pyroptosis in development, inflammation and disease.Frontiers in immunology · 2022Review
- Chicken-Specific Kinome Analysis of Early Host Immune Signaling Pathways in the Cecum of Newly Hatched Chickens Infected WithFrontiers in cellular and infection microbiology · 2022Article
- The Interplay betweenPathogens (Basel, Switzerland) · 2021Review
- Immunological and bacteriological shifts associated with a flagellin-hyperproducing Salmonella Enteritidis mutant in chickens.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- The Potential of Toll-Like Receptors to Modulate Avian Immune System: Exploring the Effects of Genetic Variants and Phytonutrients.Frontiers in genetics · 2021Review
- Activation of Toll-like receptor 5 in microglia modulates their function and triggers neuronal injury.Acta neuropathologica communications · 2020Article
- Gut microbiota composition before infection determines the Salmonella super- and low-shedder phenotypes in chicken.Microbial biotechnology · 2020Article
- Biological Activity of Porcine Gastric Mucin on Stress Resistance and Immunomodulation.Molecules (Basel, Switzerland) · 2020Article
- Mannose-Modified Chitosan-Nanoparticle-BasedVaccines · 2020Article
- Differential Response of the Chicken Trachea to Chronic Infection with Virulent Mycoplasma gallisepticum Strain Ap3AS and Vaxsafe MG (Strain ts-304): a Transcriptional Profile.Infection and immunity · 2020Article
- GtxA is a virulence factor that promotes a Th2-like response during Gallibacterium anatis infection in laying hens.Veterinary research · 2020Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Toll-like receptors (TLRs) are a major component of the pattern recognition receptor repertoire that detect invading microorganisms and direct the vertebrate immune system to eliminate infection. In chickens, the differential biology of Salmonella serovars (systemic versus gut-restricted localization) correlates with the presence or absence of flagella, a known TLR5 agonist. Chicken TLR5 (chTLR5) exhibits conserved sequence and structural similarity with mammalian TLR5 and is expressed in tissues and cell populations of immunological and stromal origin. Exposure of chTLR5+ cells to flagellin induced elevated levels of chicken interleukin-1beta (chIL-1beta) but little upregulation of chIL-6 mRNA. Consistent with the flagellin-TLR5 hypothesis, an aflagellar Salmonella enterica serovar Typhimurium fliM mutant exhibited an enhanced ability to establish systemic infection. During the early stages of infection, the fliM mutant induced less IL-1beta mRNA and polymorphonuclear cell infiltration of the gut. Collectively, the data represent the identification and functional characterization of a nonmammalian TLR5 and indicate a role in restricting the entry of flagellated Salmonella into systemic sites of the chicken.
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