ArticleInfection and immunity2005
Gene expression in Porphyromonas gingivalis after contact with human epithelial cells.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 58 citations in OpenAlex.
- Secretome of Paenibacillus sp. S-12 provides an insight about its survival and possible pathogenicity.Folia microbiologica · 2023Article
- Contribution of -Omics Technologies in the Study ofInternational journal of molecular sciences · 2022Review
- Secretome analysis of an environmental isolate Enterobacter sp. S-33 identifies proteins related to pathogenicity.Archives of microbiology · 2022Article
- Galactose Impacts the Size and Intracellular Composition of the Asaccharolytic Oral Pathobiont Porphyromonas gingivalis.Applied and environmental microbiology · 2019Article
- Gene expression of Porphyromonas gingivalis ATCC 33277 when growing in an in vitro multispecies biofilm.PloS one · 2019Article
- Proteomic Analysis and Virulence Assessment ofFrontiers in cellular and infection microbiology · 2019Article
- Relative effectiveness of azithromycin in killing intracellular Porphyromonas gingivalis.Clinical and experimental dental research · 2016Article
- Microarray analysis of the transcriptional responses of Porphyromonas gingivalis to polyphosphate.BMC microbiology · 2014Article
- Oral mucosal lipids are antibacterial against Porphyromonas gingivalis, induce ultrastructural damage, and alter bacterial lipid and protein compositions.International journal of oral science · 2013Article
- 25-Hydroxyvitamin D(3)-loaded PLA microspheres: in vitro characterization and application in diabetic periodontitis models.AAPS PharmSciTech · 2013Article
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- Comprehensive transcriptome analysis of the periodontopathogenic bacterium Porphyromonas gingivalis W83.Journal of bacteriology · 2012Article
- Genomic comparison of invasive and rare non-invasive strains reveals Porphyromonas gingivalis genetic polymorphisms.Journal of oral microbiology · 2011Article
- Antibacterial action of polyphosphate on Porphyromonas gingivalis.Antimicrobial agents and chemotherapy · 2011Article
- The core genome of the anaerobic oral pathogenic bacterium Porphyromonas gingivalis.BMC microbiology · 2010Article
- Tetratricopeptide repeat protein-associated proteins contribute to the virulence of Porphyromonas gingivalis.Infection and immunity · 2010Article
- Bacterial invasion of epithelial cells and spreading in periodontal tissue.Periodontology 2000 · 2010Review
- Porphyromonas gingivalis ferrous iron transporter FeoB1 influences sensitivity to oxidative stress.Infection and immunity · 2010Article
- Production of Monoclonal Antibodies Specific to FimA of Porphyromonas gingivalis and Their Inhibitory Activity on Bacterial Binding.Immune network · 2009Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Porphyromonas gingivalis, a gram-negative oral anaerobe, is strongly associated with adult periodontitis. The adherence of the organism to host epithelium signals changes in both cell types as bacteria initiate infection and colonization and epithelial cells rally their defenses. We hypothesized that the expression of a defined set of P. gingivalis genes would be consistently up-regulated during infection of HEp-2 human epithelial cells. P. gingivalis genome microarrays were used to compare the gene expression profiles of bacteria that adhered to HEp-2 cells and bacteria that were incubated alone. Genes whose expression was temporally up-regulated included those involved in the oxidative stress response and those encoding heat shock proteins that are essential to maintaining cell viability under adverse conditions. The results suggest that contact with epithelial cells induces in P. gingivalis stress-responsive pathways that promote the survival of the bacterium.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.