ArticleInfection and immunity2005
The natural killer complex regulates severe malarial pathogenesis and influences acquired immune responses to Plasmodium berghei ANKA.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 60 citations in OpenAlex.
- Experimental Models to Study the Pathogenesis of Malaria-Associated Acute Respiratory Distress Syndrome.Frontiers in cellular and infection microbiology · 2022Review
- Interaction Between Innate Lymphoid Cells and the Nervous System.Advances in experimental medicine and biology · 2022Review
- Contributions of natural killer cells to the immune response against Plasmodium.Malaria journal · 2019Review
- NK Cells: Uncertain Allies against Malaria.Frontiers in immunology · 2017Review
- A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP1Scientific reports · 2016Article
- Pathogenic CD8+ T cells in experimental cerebral malaria.Seminars in immunopathology · 2015Review
- Effect of chronic khat (Catha edulis, Forsk) use on outcome of Plasmodium berghei ANKA infection in Swiss albino mice.BMC infectious diseases · 2015Article
- Human Gene Expression in Uncomplicated Plasmodium falciparum Malaria.Journal of immunology research · 2015Article
- Plasmodium berghei infection ameliorates atopic dermatitis-like skin lesions in NC/Nga mice.Allergy · 2014Article
- The role of chemokines in severe malaria: more than meets the eye.Parasitology · 2014Review
- Cerebral malaria: gamma-interferon redux.Frontiers in cellular and infection microbiology · 2014Review
- Article
- The contribution of natural killer complex loci to the development of experimental cerebral malaria.PloS one · 2014Article
- Genetic variation of the natural killer gene complex has a role in lung cancer susceptibility.Journal of thoracic disease · 2013Article
- CD19(+) B cells confer protection against experimental cerebral malaria in semi-immune rodent model.PloS one · 2013Article
- CD4+ natural regulatory T cells prevent experimental cerebral malaria via CTLA-4 when expanded in vivo.PLoS pathogens · 2010Article
- Microbial induction of vascular pathology in the CNS.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2010Review
- Natural regulatory T cells in malaria: host or parasite allies?PLoS pathogens · 2010Review
- An early burst of IFN-gamma induced by the pre-erythrocytic stage favours Plasmodium yoelii parasitaemia in B6 mice.Malaria journal · 2009Article
- Natural killer cells in immunodefense against infective agents.Expert review of anti-infective therapy · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
The natural killer complex (NKC) is a genetic region of highly linked genes encoding several receptors involved in the control of NK cell function. The NKC is highly polymorphic, and allelic variability of various NKC loci has been demonstrated in inbred mice. Making use of BALB.B6-Cmv1r congenic mice, in which the NKC from disease-susceptible C57BL/6 mice has been introduced into the disease-resistant BALB/c background, we show here that during murine malaria infection, the NKC regulates a range of pathophysiological syndromes such as cerebral malaria, pulmonary edema, and severe anemia, which contribute to morbidity and mortality in human malaria. Parasitemia levels were not affected by the NKC genotype, indicating that control of malarial fatalities by the NKC cells does not operate through effects on parasite growth rate. Parasite-specific antibody responses and the proinflammatory gene transcription profile, as well as the TH1/TH2 balance, also appeared to be influenced by NKC genotype, providing evidence that this region, known to control innate immune responses via NK and/or NK T-cell activation, can also significantly regulate acquired immunity to infection. To date, NKC-encoded innate system receptors have been shown mainly to regulate viral infections. Our data provide evidence for critical NKC involvement in the broad immunological responses to a protozoan parasite.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.