ArticleInfection and immunity2005
Immunoglobulin G isotype responses to erythrocyte surface-expressed variant antigens of Plasmodium falciparum predict protection from malaria in African children.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Antibodies to PfEMP1 and variant surface antigens: Protection after controlled human malaria infection in semi-immune Kenyan adults.The Journal of infection · 2024Article
- DHEA Induces Sex-Associated Differential Patterns in Cytokine and Antibody Levels in Mice Infected withInternational journal of molecular sciences · 2023Article
- IgG isotypic antibodies to crude Plasmodium falciparum blood-stage antigen associated with placental malaria infection in parturient Cameroonian women.African health sciences · 2016Article
- The role of PfEMP1 as targets of naturally acquired immunity to childhood malaria: prospects for a vaccine.Parasitology · 2016Review
- Surface antigens of Plasmodium falciparum-infected erythrocytes as immune targets and malaria vaccine candidates.Cellular and molecular life sciences : CMLS · 2014Review
- Decreased growth rate of P. falciparum blood stage parasitemia with age in a holoendemic population.The Journal of infectious diseases · 2014Article
- Article
- The dynamics of naturally acquired immunity to Plasmodium falciparum infection.PLoS computational biology · 2012Article
- The humoral response to Plasmodium falciparum VarO rosetting variant and its association with protection against malaria in Beninese children.Malaria journal · 2010Article
- Acquired immunity to malaria.Clinical microbiology reviews · 2009Review
- Article
- Differential evolution of anti-VAR2CSA- IgG3 in primigravidae and multigravidae pregnant women infected by Plasmodium falciparum.Malaria journal · 2008Article
- Article
- Placental malaria induces variant-specific antibodies of the cytophilic subtypes immunoglobulin G1 (IgG1) and IgG3 that correlate with adhesion inhibitory activity.Infection and immunity · 2005Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We assessed immunoglobulin G (IgG) isotype responses to variant surface antigens (VSA) expressed on parasite-infected erythrocytes of a panel of heterologous isolates during and after acute episodes in groups of Gabonese children presenting with either mild or severe Plasmodium falciparum malaria. In the acute and convalescent phases IgG3 and IgG1 anti-VSA antibodies, respectively, predominated. In the absence of infection, the levels of both cytophilic isotypes waned, while those of IgG4 increased, particularly in those admitted with severe malaria. Prospective analyses showed significantly longer delays between malaria attacks associated both (i) with increasing IgG1 responses with specificity for VSA of isolates from children with mild malaria and (ii) with increasing IgG4 responses with specificity for VSA of isolates from children with severe malaria. These findings imply that the predictive value of prospectively measured cross-reactive VSA-specific IgG antibodies with respect to protection against malaria in African children depends both on their isotype and on their fine specificity.
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