ArticleInfection and immunity2005
Yersinia pestis V protein epitopes recognized by CD4 T cells.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- IgG antibodies anti-LcrV of Yersinia pestis: inconsistent responses in confirmed plague patients from Madagascar.BMC research notes · 2025Article
- CD4+ T-Cell Epitope Prediction by Combined Analysis of Antigen Conformational Flexibility and Peptide-MHCII Binding Affinity.Biochemistry · 2022Article
- Polymorphism in theFrontiers in immunology · 2019Article
- Genetic variation at the MHC DRB1 locus is similar across Gunnison's prairie dog (Cynomys gunnisoni) colonies regardless of plague history.Ecology and evolution · 2016Article
- Repertoire of HLA-DR1-restricted CD4 T-cell responses to capsular Caf1 antigen of Yersinia pestis in human leukocyte antigen transgenic mice.Infection and immunity · 2010Article
- Article
- Absence of inflammation and pneumonia during infection with nonpigmented Yersinia pestis reveals a new role for the pgm locus in pathogenesis.Infection and immunity · 2010Article
- Amino acid and structural variability of Yersinia pestis LcrV protein.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2010Article
- Dual-function antibodies to Yersinia pestis LcrV required for pulmonary clearance of plague.Clinical and vaccine immunology : CVI · 2009Article
- D27-pLpxL, an avirulent strain of Yersinia pestis, primes T cells that protect against pneumonic plague.Infection and immunity · 2009Article
- Immune defense against pneumonic plague.Immunological reviews · 2008Review
- Broad T cell immunity to the LcrV virulence protein is induced by targeted delivery to DEC-205/CD205-positive mouse dendritic cells.European journal of immunology · 2008Article
- Study of proinflammatory responses induced by Yersinia pestis in human monocytes using cDNA arrays.Genes and immunity · 2007Article
- Mechanisms of major histocompatibility complex class II-restricted processing and presentation of the V antigen of Yersinia pestis.Immunology · 2006Article
- Cell-mediated protection against pulmonary Yersinia pestis infection.Infection and immunity · 2005Article
- Prediction of antigenically active regions in the OmpF-like porin of Yersinia pseudotuberculosis.Doklady. Biochemistry and biophysicsArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Pneumonic plague, an often-fatal disease for which no vaccine is presently available, results from pulmonary infection by the bacterium Yersinia pestis. The Y. pestis V protein is a promising vaccine candidate, as V protein immunizations confer to mice significant protection against aerosolized Y. pestis. CD4 T cells play central roles during vaccine-primed immune responses, but their functional contributions to Y. pestis vaccines have yet to be evaluated and optimized. Toward that end, we report here the identification of three distinct epitopes within the Y. pestis V protein that activate CD4 T cells in C57BL/6 mice. To our knowledge, these are the first identified CD4 T-cell epitopes in any Y. pestis protein. The epitopes are restricted by the I-A(b) class II major histocompatibility complex molecule and are fully conserved between Y. pestis, Yersinia pseudotuberculosis, and Yersinia enterocolitica. Immunizing mice with a V protein-containing vaccine or with short peptides containing the identified epitopes primes antigen-specific production of interleukin 2 and gamma interferon by CD4 T cells upon their restimulation in vitro. Consistent with prior studies documenting protective roles for CD4 T cells during Y. enterocolitica infection, vaccinating mice with a 16-amino-acid peptide encoding one of the epitopes suffices to protect against an otherwise lethal Y. enterocolitica challenge. The identification of these epitopes will permit quantitative assessments of V-specific CD4 T cells, thereby enabling researchers to evaluate and optimize the contribution of these cells to vaccine-primed protection against pneumonic plague.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.