ArticleInfection and immunity2005
Effect of B7-2 and CD40 signals from activated antigen-presenting cells on the ability of zwitterionic polysaccharides to induce T-Cell stimulation.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
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- A novel strain of Bacteroides fragilis enhances phagocytosis and polarises M1 macrophages.Scientific reports · 2016Article
- A commensal symbiotic factor derived from Bacteroides fragilis promotes human CD39(+)Foxp3(+) T cells and Treg function.Gut microbes · 2015Article
- Plasmacytoid dendritic cells mediate anti-inflammatory responses to a gut commensal molecule via both innate and adaptive mechanisms.Cell host & microbe · 2014Article
- MHCII glycosylation modulates Bacteroides fragilis carbohydrate antigen presentation.The Journal of experimental medicine · 2011Article
- Glycoantigens induce human peripheral Tr1 cell differentiation with gut-homing specialization.The Journal of biological chemistry · 2011Article
- Carbohydrate oxidation acidifies endosomes, regulating antigen processing and TLR9 signaling.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- The modulation of adaptive immune responses by bacterial zwitterionic polysaccharides.International journal of microbiology · 2010Article
- Beneficial effects of Bacteroides fragilis polysaccharides on the immune system.Frontiers in bioscience (Landmark edition) · 2010Review
- Toll-like receptor 2 dependent immunogenicity of glycoconjugate vaccines containing chemically derived zwitterionic polysaccharides.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Streptococcus pneumoniae serotype 1 capsular polysaccharide induces CD8CD28 regulatory T lymphocytes by TCR crosslinking.PLoS pathogens · 2009Article
- Type I Streptococcus pneumoniae carbohydrate utilizes a nitric oxide and MHC II-dependent pathway for antigen presentation.Immunology · 2009Article
- Generation of antibody responses to pneumococcal capsular polysaccharides is independent of CD1 expression in mice.Infection and immunity · 2009Article
- Characteristics of carbohydrate antigen binding to the presentation protein HLA-DR.Glycobiology · 2008Article
- Transport of Streptococcus pneumoniae capsular polysaccharide in MHC Class II tubules.PLoS pathogens · 2007Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Carbohydrates have been thought to stimulate immune responses independently of T cells; however, zwitterionic polysaccharides (ZPSs) from the capsules of some bacteria elicit potent CD4+-T-cell responses in vivo and in vitro. We demonstrated that HLA-DR on professional antigen-presenting cells (APCs) is required for ZPS-induced T-cell proliferation in vitro (15). Recently, it was shown that ZPSs are processed to low-molecular-weight carbohydrates by a nitric oxide-mediated mechanism in endosomes and locate in the major histocompatibility complex class II pathway (5, 15). The effect of the ZPS-mediated expression of HLA-DR and costimulatory molecules on the APC and T-cell engagement and subsequent T-cell activation has not been elucidated. Herein, we report that ZPS-mediated induction of HLA-DR-surface expression and T-cell proliferation are maximally enhanced after incubation of APCs for 8 h with ZPS. Treatment of APCs with bafilomycin A inhibits the up-regulation of ZPS-mediated HLA-DR surface expression and leads to inhibition of T-cell proliferation. Monoclonal antibodies (MAbs) to the costimulatory molecules B7-2 and CD40L specifically block ZPS-mediated T-cell activation, while a MAb to B7-1 does not. Surface expression of B7-2 and B7-1 but not of CD40 is maximally enhanced at 8 to 16 h of treatment of APCs with ZPS. The results demonstrate that the cellular immune response to ZPS depends on the translocation of HLA-DR to the cell surface and requires costimulation via B7-2 and CD40 on activated APCs. The implication is that activation of ZPS-specific T cells requires an orchestrated arrangement of both presenting and costimulatory molecules to form an immunological synapse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.