ArticleJournal of cellular and molecular medicine
A concept on the role of Helicobacter pylori infection in autoimmune pancreatitis.
Article in Journal of cellular and molecular medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 98 citations in OpenAlex.
- Autoimmune Polyglandular Syndrome Type 3 Complicated with IgG4-related Disease.Internal medicine (Tokyo, Japan) · 2024Article
- IgG4 autoantibodies and autoantigens in the context of IgG4-autoimmune disease and IgG4-related disease.Frontiers in immunology · 2024Review
- Tormentic acid, a triterpenoid isolated from the fruits ofPharmaceutical biology · 2023Article
- The Probable Infectious Origin of Multiple Sclerosis.NeuroSci · 2023Review
- Potential Impact of Helicobacter pylori Infection on Pancreatic Cancer Pathophysiology.Journal of gastrointestinal cancer · 2023Article
- Review
- Review of Diagnostic Biomarkers in Autoimmune Pancreatitis: Where Are We Now?Diagnostics (Basel, Switzerland) · 2021Review
- IgG4-related disease: Changing epidemiology and new thoughts on a multisystem disease.Journal of translational autoimmunity · 2021Review
- Helicobacter pylori and its association with autoimmune diseases: systemic lupus erythematosus, rheumatoid arthritis and Sjögren syndrome.Journal of translational autoimmunity · 2021Article
- Association between ActiveMicroorganisms · 2020Review
- Article
- Human Gut Microbiota and Gastrointestinal Cancer.Genomics, proteomics & bioinformatics · 2018Review
- Current perspectives on autoimmune pancreatitis and IgG4-related disease.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2018Review
- Testing for Anti-PBP Antibody Is Not Useful in Diagnosing Autoimmune Pancreatitis.The American journal of gastroenterology · 2016Article
- IgG4-related hepatobiliary disease: an overview.Nature reviews. Gastroenterology & hepatology · 2016Review
- Extragastric manifestations of Helicobacter pylori infection: Possible role of bacterium in liver and pancreas diseases.World journal of hepatology · 2015Review
- IgG4-associated cholangitis: a comprehensive review.Clinical reviews in allergy & immunology · 2015Review
- Improvement of Idiopathic Cardiomyopathy After Colon Clear.Cardiology research · 2015Article
- Rare case of Helicobacter pylori-positive multiorgan IgG4-related disease and gastric cancer.World journal of gastroenterology · 2015Article
- IgG4-related autoimmune diseases: Polymorphous presentation complicates diagnosis and treatment.Deutsches Arzteblatt international · 2015Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autoimmune pancreatitis, an inflammatory process of the pancreas due to an autoimmune mechanism establishing etiology of chronic pancreatitis, is characterized by the presence of autoantibodies, hypergammaglobulinemia, pancreatic enlargement, pancreatic duct strictures, and pathologic features of fibrotic changes with intense, mainly lymphocytic infiltrations, which may contribute to tissue destruction probably by apoptosis. In almost 60% of the cases, this type of pancreatitis coexists with other autoimmune diseases such as Sjogren's syndrome, sclerosing extrahepatic cholangitis, primary biliary cirrhosis, autoimmune hepatitis, or other extrapancreatic disorders, and recently with gastric peptic ulceration. The diversity of extrapancreatic lesions with similar histopathologic findings suggests general involvement of the digestive system in this disease, although the presence of such involvement has not been fully elucidated. Similarly, Helicobacter pylori (H. pylori) infection, a well known cause of gastric ulcer, has been associated, via molecular mimicry of host structures by its constituents with the same autoimmune conditions, also characterized by fibrotic changes and/or lymphoplasmacytic inflammations, accompanied by aberrations of T cell apoptosis that contribute to hepatobiliary- or extrahepatic-tissue destruction. Considering that H. pylori is involved in the pathogenesis and pathophysiology of these autoimmune disorders, we propose that this organism might trigger autoimmune pancreatitis through induction of autoimmunity and apoptosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.