ArticleJournal of cellular and molecular medicine
Expression of scaffolding, signalling and contractile-filament proteins in human myometria: effects of pregnancy and labour.
Article in Journal of cellular and molecular medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- RAC1 is involved in uterine myometrium contraction in the inflammation-associated preterm birth.Reproduction (Cambridge, England) · 2022Article
- Misleading Westerns: Common Quantification Mistakes in Western Blot Densitometry and Proposed Corrective Measures.BioMed research international · 2019Article
- Inhibition of Uterine Contractility by Thalidomide Analogs via Phosphodiesterase-4 Inhibition and Calcium Entry Blockade.Molecules (Basel, Switzerland) · 2016Article
- Article
- Decreased myometrial p160 ROCK-1 expression in obese women at term pregnancy.Reproductive biology and endocrinology : RB&E · 2013Article
- Effect of estrogen on molecular and functional characteristics of the rodent vaginal muscularis.The journal of sexual medicine · 2013Article
- Development and validation of primary human myometrial cell culture models to study pregnancy and labour.BMC pregnancy and childbirth · 2013Article
- Phasic contractions of isolated human myometrium are associated with Rho-kinase (ROCK)-dependent phosphorylation of myosin phosphatase-targeting subunit (MYPT1).Molecular human reproduction · 2012Article
- Altered contribution of RhoA/Rho kinase signaling in contractile activity of myometrium in leptin receptor-deficient mice.American journal of physiology. Endocrinology and metabolism · 2011Article
- Article
- Prostacyclin primes pregnant human myometrium for an enhanced contractile response in parturition.The Journal of clinical investigation · 2008Article
- Myometrial mechanoadaptation during pregnancy: implications for smooth muscle plasticity and remodelling.Journal of cellular and molecular medicine · 2008Article
- In vivo and in vitro effects of Bidens pilosa L. (Asteraceae) leaf aqueous and ethanol extracts on primed-oestrogenized rat uterine muscle.African journal of traditional, complementary, and alternative medicines : AJTCAM · 2007Article
- Towards understanding the myometrial physiome: approaches for the construction of a virtual physiological uterus.BMC pregnancy and childbirth · 2007Review
- Regulation of the uterine contractile apparatus and cytoskeleton.Seminars in cell & developmental biology · 2007Review
- Gestational-dependent changes in the expression of signal transduction and contractile filament-associated proteins in mouse myometrium.Journal of the Society for Gynecologic Investigation · 2005Article
- Caveolae in smooth muscles: nanocontacts.Journal of cellular and molecular medicineArticle
- Caveolar nanospaces in smooth muscle cells.Journal of cellular and molecular medicineArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
Successful parturition requires the co-ordination of numerous myometrial signalling events to allow for timely and efficient uterine contractions. Late pregnancy and labour onset in humans may be associated with changes in the expression of myometrial proteins implicated in such uterine contractile signal integration. Accordingly, in myometria from non-pregnant women and pregnant women, not in labour or in labour, we examined the content of putative plasmalemmal scaffolding proteins (caveolin-1 and -2) and compared these to the proportions of signal transducing rho-associated kinases (ROKalpha and beta) and contractile filament-associated proteins alpha-actin, myosin regulatory light chain (MLC(20)) and h-caldesmon. There was no effect of pregnancy or labour on the proportion of caveolin, ROK betaor alpha-actin. However, pregnancy was associated with a decrease in ROKalpha and MLC(20) such that ROK alpha: alpha-actin and MLC(20): alpha-actin ratios were reduced compared to myometria of non-pregnant women. In contrast, h-caldesmon was up-regulated in pregnancy resulting in an elevated h-caldesmon: alpha-actin ratio. There were, however, no further significant changes in ROK alpha, MLC(20) or h-caldesmon expression with spontaneous or oxytocin-induced labour. These data suggest that the mechanism(s) integrating myometrial signalling events with the onset of human labour does not involve differential alterations of the cellular expressions of caveolins, ROK, alpha-actin, MLC(20) or h-caldesmon.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.