ArticlePhysical review. E, Statistical, nonlinear, and soft matter physics2005
Coupled dynamics of voltage and calcium in paced cardiac cells.
Article in Physical review. E, Statistical, nonlinear, and soft matter physics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
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Who cites it
80 citing papers in PubMed.
- Beat-to-beat QT interval variability as a tool to detect the underlying cellular mechanisms of arrhythmias.The Journal of physiology · 2025Article
- Impact of Calcium and Potassium Currents on Spiral Wave Dynamics in the LR1 Model.Entropy (Basel, Switzerland) · 2025Article
- Modeling autoregulation of cardiac excitation-Ca-contraction and arrhythmogenic activities in response to mechanical load changes.iScience · 2025Article
- Dynamical effects of mechano-chemo-transduction on cardiac alternans.Biophysical journal · 2025Article
- Intracellular ion accumulation in the genesis of complex action potential dynamics under cardiac diseases.Physical review. E · 2024Article
- Dissecting the roles of calcium cycling and its coupling with voltage in the genesis of early afterdepolarizations in cardiac myocyte models.PLoS computational biology · 2024Article
- Native mechano-regulative matrix properties stabilize alternans dynamics and reduce spiral wave stabilization in cardiac tissue.Frontiers in network physiology · 2024Article
- The calcium transient coupled to the L-type calcium current attenuates cardiac alternans.Frontiers in physiology · 2024Article
- Long-term changes in heart rate and electrical remodeling contribute to alternans formation in heart failure: a patient-specific in silico study.American journal of physiology. Heart and circulatory physiology · 2023Article
- Mechanisms of spontaneous CaThe Journal of physiology · 2023Article
- Simultaneous Widefield Voltage and Dye-Free Optical Mapping Quantifies Electromechanical Waves in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.ACS photonics · 2023Article
- Optical mapping of contracting hearts.The Journal of physiology · 2023Review
- Cardiac Alternans: From Bedside to Bench and Back.Circulation research · 2023Review
- Biological noise is a key determinant of the reproducibility and adaptability of cardiac pacemaking and EC coupling.The Journal of general physiology · 2022Review
- Synchronization of spatially discordant voltage and calcium alternans in cardiac tissue.Physical review. E · 2022Article
- The development of L-type CaScientific reports · 2021Article
- Experimental induction and mathematical modeling ofChannels (Austin, Tex.) · 2020Article
- Stability of spatially discordant repolarization alternans in cardiac tissue.Chaos (Woodbury, N.Y.) · 2020Article
- Delayed global feedback in the genesis and stability of spatiotemporal excitation patterns in paced biological excitable media.PLoS computational biology · 2020Article
- Dual regulation by subcellular calcium heterogeneity and heart rate variability on cardiac electromechanical dynamics.Chaos (Woodbury, N.Y.) · 2020Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
We investigate numerically and analytically the coupled dynamics of transmembrane voltage and intracellular calcium cycling in paced cardiac cells using a detailed physiological model, and its reduction to a three-dimensional discrete map. The results provide a theoretical framework to interpret various experimentally observed modes of instability ranging from electromechanically concordant and discordant alternans to quasiperiodic oscillations of voltage and calcium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.