ArticlePediatric nephrology (Berlin, Germany)2005
Growth hormone for children with chronic renal failure and on dialysis.
Article in Pediatric nephrology (Berlin, Germany), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00943995 (TIW Growth Hormone Therapy in Children on Hemodialysis), which is not on this map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
TIW Growth Hormone Therapy in Children on Hemodialysis
Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Growth hormone therapy in children with CKD after more than two decades of practice.Pediatric nephrology (Berlin, Germany) · 2016Review
- Long-term results of rhGH treatment in children with renal failure: experience of the French Society of Pediatric Nephrology.Pediatric nephrology (Berlin, Germany) · 2008Article
- Linear growth in pediatric hemodialysis patients.Pediatric nephrology (Berlin, Germany) · 2008Article
- Growth of prepubertal children on dialysis.Pediatric nephrology (Berlin, Germany) · 2007Review
- Use of rhGH in children with chronic kidney disease: lessons from NAPRTCS.Pediatric nephrology (Berlin, Germany) · 2007Article
- Assessment and treatment of short stature in pediatric patients with chronic kidney disease: a consensus statement.Pediatric nephrology (Berlin, Germany) · 2006Article
- Longitudinal growth in children following kidney transplantation: from conservative to pharmacological strategies.Pediatric nephrology (Berlin, Germany) · 2006Review
- Report of an NIH task force on research priorities in chronic kidney disease in children.Pediatric nephrology (Berlin, Germany) · 2006Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied all children with CRF who received recombinant human growth hormone (rhGH) for more than a year (mean+/-SD duration of therapy 3.7+/-2.5 years) over an 11-year period. There were 32 children. Twenty-one children were conservatively managed, with a mean glomerular filtration rate (GFR) of 24+/-12 mL min(-1)/1.73 m2 at the start of rhGH. Their height standard deviation score improved from -2.5+/-1.4 to -2.1+/-0.7 at 1 year (P=0.3), -2.0+/-0.7 at 2 years (P=0.01), and -1.6+/-0.6 at 3 years (P=0.001). After that there was no improvement. Eleven children were on dialysis, six on haemodialysis (HD) and five on peritoneal (PD). Ht SDS improved from -2.7+/-0.5 to -2.3+/-0.5 at 1 year (P=0.02). Thereafter there was no further improvement. RhGH was stopped because of transplantation in 29 patients at a mean+/-SD age of 12.1+/-4.0 years. Mean Ht SDS was -1.8+/-0.8 at transplant and there was no change over the following 5 years. In conclusion, treatment with rhGH resulted in improvement in Ht SDS in conservatively managed CRF for up to 3.0 years and for 1 year in children on dialysis. Discontinuation of rhGH after transplantation resulted in little change in Ht SDS.
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Registered trials
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