ArticlePediatric nephrology (Berlin, Germany)2005
Dysregulation of renal MMP-3 and MMP-7 in canine X-linked Alport syndrome.
Article in Pediatric nephrology (Berlin, Germany), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Genotype-Based Molecular Mechanisms in Alport Syndrome.Journal of the American Society of Nephrology : JASN · 2025Review
- MMP-3 activation is involved in copper oxide nanoparticle-induced epithelial-mesenchymal transition in human lung epithelial cells.Nanotoxicology · 2021Article
- Matrix metalloproteinase-2, -7, and -9 activities in dogs with idiopathic pulmonary fibrosis compared to healthy dogs and dogs with other respiratory diseases.Journal of veterinary internal medicine · 2021Article
- Matrix Metalloproteinases-7 and Kidney Fibrosis.Frontiers in physiology · 2017Review
- Soluble biglycan as a biomarker of inflammatory renal diseases.The international journal of biochemistry & cell biology · 2014Review
- An update on the pathomechanisms and future therapies of Alport syndrome.Pediatric nephrology (Berlin, Germany) · 2013Review
- Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis.The American journal of pathology · 2011Article
- Matrix metalloproteinases: their potential role in the pathogenesis of diabetic nephropathy.Endocrine · 2009Review
- Glomerular matrix metalloproteinases and their regulators in the pathogenesis of lupus nephritis.Arthritis research & therapy · 2008Review
- Gene expression analysis in a canine model of X-linked Alport syndrome.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Article
- Role for macrophage metalloelastase in glomerular basement membrane damage associated with alport syndrome.The American journal of pathology · 2006Article
- Epigallocatechin-3-gallate attenuates arsenic-induced fibrogenic changes in human kidney epithelial cells through reversal of epigenetic aberrations and antioxidant activities.BioFactors (Oxford, England)Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
Matrix metalloproteinases (MMPs) play an important regulatory role in many biological and pathological processes and their specific role in Alport syndrome (AS) is not yet clearly defined. In this study, the naturally occurring canine X-linked AS was used to demonstrate a potential role for MMP-3 and MMP-7 in Alport renal pathogenesis. Recently, we demonstrated that the expression of MMP-2, MMP-9 and MMP-14 was upregulated in the renal cortex of dogs with a spontaneous form of XLAS. In the present study, we examined necropsy samples of renal cortex from normal and XLAS dogs for MMP-3 and MMP-7 as they have the potential to activate MMP-2 and MMP-9. Immunohistochemical analysis showed strong immunostaining for both MMP-3 and MMP-7 in the interstitial space of XLAS kidneys, while virtually no immunostaining was observed in similar fields from normal dogs. RT-PCR and casein zymography confirmed that both mRNA transcripts and activities of MMP-3 and MMP-7 are elevated in XLAS kidneys. The induction of these MMPs likely contributes to tissue destruction associated with the fibrogenic process, while augmenting the activation of MMP-2 and MMP-9 by MMP-3 and MMP-7 in XLAS. Thus, these data further implicate a role for the MMPs in progressive renal pathogenesis associated with AS.
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Registered trials
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