ReviewPediatric nephrology (Berlin, Germany)2005
Heat-shock protein 70: molecular supertool?
Review in Pediatric nephrology (Berlin, Germany), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Involvement of heat shock proteins HSP70 in the mechanisms of endogenous neuroprotection: the prospect of using HSP70 modulators.Frontiers in cellular neuroscience · 2023Pooled it
- Effects of initial periodontal treatment on heat shock protein 90 and Interleukin-1β levels in gingival crevicular fluid of stage III periodontitis patients.BMC oral health · 2025Article
- Therapeutic hyperthermia promotes lipid export and HSP70/90 during machine perfusion of human livers.Physiological reports · 2025Article
- Acclimatization response to a short-term heat wave during summer in lactating Brown Swiss and Holstein Friesian cows.Frontiers in veterinary science · 2025Article
- Reduction of Renal Preservation/Reperfusion Injury by Controlled Hyperthermia During Ex Vivo Machine Perfusion.Clinical and translational science · 2021Article
- Increase of Hspa1a and Hspa1b genes in the resting B cells of Sirt1 knockout mice.Molecular biology reports · 2019Article
- Changes in chosen immune system indicators and the level of HSP-70 after single whole-body cryostimulation in healthy men.Central-European journal of immunology · 2018Article
- Expression dynamics of HSP70 during chronic heat stress in Tharparkar cattle.International journal of biometeorology · 2017Article
- Heat shock proteins and kidney disease: perspectives of HSP therapy.Cell stress & chaperones · 2017Review
- Mediators and mechanisms of heat shock protein 70 based cytoprotection in obstructive nephropathy.Cell stress & chaperones · 2015Review
- Overexpression of Hsp70 confers cytoprotection during gliadin exposure in Caco-2 cells.Pediatric research · 2015Article
- Novel SNPs in HSP70A1A gene and the association of polymorphisms with thermo tolerance traits and tissue specific expression in Chinese Holstein cattle.Molecular biology reports · 2011Article
- Heat shock protein 70 induction and its urinary excretion in a model of acetaminophen nephrotoxicity.Pediatric nephrology (Berlin, Germany) · 2010Article
- Cellular stress-response modulators in the acute rat model of peritoneal dialysis.Pediatric nephrology (Berlin, Germany) · 2010Article
- The HSP72 stress response of monocytes from patients on haemodialysis is impaired.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2009Article
- Expression of the RNA-stabilizing protein HuR in ischemia-reperfusion injury of rat kidney.American journal of physiology. Renal physiology · 2009Article
- Article
- Proteomics for biomarker discovery in acute kidney injury.Seminars in nephrology · 2007Review
- Variability of naked DNA expression after direct local injection: the influence of the injection speed.Gene therapy · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cellular stress response decreases cellular injury, either via primary induction of cytoresistance or by secondary enhancement of cellular repair mechanisms. The most frequently studied and best understood effectors of the cellular stress response are the heat shock proteins (HSP). HSP are among the oldest tools in the cellular protein machinery, demonstrating extremely high conservation of the genetic code since bacteria. Molecular chaperons, with the HSP-70 being the prototype, cooperate in transport and folding of proteins, preventing aggregation, and even resolubilizing injured proteins. Increasing evidence supports a role for HSP during the recovery from renal ischemia, in particular in cellular salvage from apoptotic cell death and cytoskeletal restoration. Recent studies also report the potential for biomolecular profiling of newborns for the risk of acute renal failure. In peritoneal dialysis novel data suggest the use of HSP expression for biocompatibility testing. More importantly, HSP are prime therapeutic candidates for clinical situations associated with predictable insults, such as organ procurement in transplant medicine and repetitive exposure to hyperosmolar and acidotic peritoneal dialysis fluids. The next challenge will be to define the regulatory pathways of the cellular stress response in these models to introduce novel therapeutic interventions, such as new pharmaceutics enhancing the HSP expression.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.