Evidence map›Paper›PMID 15781963›Full record

ArticleJournal of molecular neuroscience : MN2005

Orphanin FQ antagonizes the inhibition of Ca(2+) currents induced by mu-opioid receptors.

Min Zhang, Xiaomin Wang, Dabao Zhang, Guoheng Xu, Hongwei Dong, Yingxin Yu, Jisheng Han

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular neuroscience : MN, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Min ZhangNeuroscience Research Institute, Peking University, Beijing, China. mz35@cornell.edu
Xiaomin Wang
Dabao Zhang
Guoheng Xu
Hongwei Dong
Yingxin Yu
Jisheng Han
Peking University · CNCapital Medical University · CNUniversity of Rochester Medical Center · US

Funding

NIDA NIH HHS DA03983
6 · The paper itself

Abstract

Orphanin FQ (OFQ), an endogenous peptide ligand of opioid receptor-like receptors (ORLs), has properties similar to traditional opioids. This peptide inhibits adenylyl cyclase and voltage-gated calcium channels but stimulates inwardly rectifying potassium channels. Among other actions, however, OFQ also has pharmacological functions that are different from, or even opposite to, those of opioids. For example, OFQ antagonizes the behavioral analgesic effects mediated by kappa- and mu-opioid receptors. In a previous paper, we reported that OFQ antagonizes inhibition of calcium channels mediated by kappa-opioid receptors. We report here that OFQ also antagonizes the inhibition of calcium channels mediated by mu-opioid receptor. Further, single-cell RT-PCR reveals that the antagonistic effect of OFQ is correlated with the presence of ORL1 mRNA in individual cells.

Indexed as

AnalgesicsAnimalsCalciumCalcium ChannelsFentanylGanglia, SpinalMaleNeuronsNociceptinNociceptin ReceptorOpioid PeptidesPatch-Clamp TechniquesRatsRats, WistarReceptors, OpioidReceptors, Opioid, muAnalgesicsCalciumCalcium ChannelsF 7302FentanylNociceptinNociceptin ReceptorOpioid PeptidesOprl1 protein, ratReceptors, OpioidReceptors, Opioid, mu

Identifiers

PMID15781963
OpenAlexW2081043851

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.