ArticleGenetics2005
The origin of subfunctions and modular gene regulation.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 118 citations in OpenAlex.
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- The ensemble of gene regulatory networks at mutation-selection balance.Journal of the Royal Society, Interface · 2023Article
- A synthetic synthesis to explore animal evolution and development.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
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- Subfunctionalization influences the expansion of bacterial multidrug antibiotic resistance.BMC genomics · 2017Article
- Evolution of new regulatory functions on biophysically realistic fitness landscapes.Nature communications · 2017Article
- How transcription circuits explore alternative architectures while maintaining overall circuit output.Genes & development · 2017Review
- Evolutionary diversification of retinoic acid receptor ligand-binding pocket structure by molecular tinkering.Royal Society open science · 2016Article
- Nymphalid eyespots are co-opted to novel wing locations following a similar pattern in independent lineages.BMC evolutionary biology · 2015Article
- The evolutionary dynamics of major regulators for sexual development among Hymenoptera species.Frontiers in genetics · 2015Article
- Evolutionary cell biology: two origins, one objective.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Integrated phenotypes: understanding trait covariation in plants and animals.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Gene duplication as a major force in evolution.Journal of genetics · 2013Review
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- Large scale of human duplicate genes divergence.Journal of molecular evolution · 2012Article
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- Biological robustness: paradigms, mechanisms, and systems principles.Frontiers in genetics · 2012Article
- The emergence of modularity in biological systems.Physics of life reviews · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
Evolutionary explanations for the origin of modularity in genetic and developmental pathways generally assume that modularity confers a selective advantage. However, our results suggest that even in the absence of any direct selective advantage, genotypic modularity may increase through the formation of new subfunctions under near-neutral processes. Two subfunctions may be formed from a single ancestral subfunction by the process of fission. Subfunction fission occurs when multiple functions under unified genetic control become subdivided into more restricted functions under independent genetic control. Provided that population size is sufficiently small, random genetic drift and mutation can conspire to produce changes in the number of subfunctions in the genome of a species without necessarily altering the phenotype. Extensive genotypic modularity may then accrue in a near-neutral fashion in permissive population-genetic environments, potentially opening novel pathways to morphological evolution. Many aspects of gene complexity in multicellular eukaryotes may have arisen passively as population size reductions accompanied increases in organism size, with the adaptive exploitation of such complexity occurring secondarily.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.