ArticleGenetics2005
Improving quantitative trait loci mapping resolution in experimental crosses by the use of genotypically selected samples.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 53 citations in OpenAlex.
- Genome-wide association and selection studies for pod dehiscence resistance in the USDA soybean germplasm collection.PloS one · 2025Article
- Enhanced recombination empowers the detection and mapping of Quantitative Trait Loci.Communications biology · 2024Article
- Article
- Developmental Pleiotropy Shaped the Roots of the Domesticated Common Bean (Plant physiology · 2019Article
- Linkage-based genome assembly improvement of oil palm (Elaeis guineensis).Scientific reports · 2019Article
- Characterization of Transcription Factor GeneFrontiers in plant science · 2018Article
- Confirmation of delayed canopy wilting QTLs from multiple soybean mapping populations.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2015Article
- Targeted Recombinant Progeny: a design for ultra-high resolution mapping of Quantitative Trait Loci in crosses between inbred or pure lines.BMC genetics · 2015Article
- Rapid and inexpensive whole-genome genotyping-by-sequencing for crossover localization and fine-scale genetic mapping.G3 (Bethesda, Md.) · 2015Article
- The impact of recombination on short-term selection gain in plant breeding experiments.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2013Article
- The importance of chromosomes from the sixth homeologic group in the restoration of male fertility in winter triticale with Triticum timopheevii cytoplasm.Journal of applied genetics · 2013Article
- A toolkit for bulk PCR-based marker design from next-generation sequence data: application for development of a framework linkage map in bulb onion (Allium cepa L.).BMC genomics · 2012Article
- Genomic imprinting and genetic effects on muscle traits in mice.BMC genomics · 2012Article
- Use of contiguous congenic strains in analyzing compound QTLs.Physiological genomics · 2012Article
- Varying coefficient models for mapping quantitative trait loci using recombinant inbred intercrosses.Genetics · 2012Article
- Natural variation in Arabidopsis: from molecular genetics to ecological genomics.Plant physiology · 2012Review
- Selective phenotyping, entropy reduction, and the mastermind game.BMC bioinformatics · 2011Article
- Combining DNA pooling with selective recombinant genotyping for increased efficiency in fine mapping.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2010Article
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Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the key factors contributing to the success of a quantitative trait locus (QTL) mapping experiment is the precision with which QTL positions can be estimated. We show, using simulations, that QTL mapping precision for an experimental cross can be increased by the use of a genotypically selected sample of individuals rather than an unselected sample of the same size. Selection is performed using a previously described method that optimizes the complementarity of the crossover sites within the sample. Although the increase in precision is accompanied by a decrease in QTL detection power at markers distant from QTL, only a modest increase in marker density is needed to obtain equivalent power over the whole map. Selected samples also show a slight reduction in the number of false-positive QTL. We find that two features of selected samples independently contribute to these effects: an increase in the number of crossover sites and increased evenness in crossover spacing. We provide an empirical formula for crossover enrichment in selected samples that is useful in experimental design and data analysis. For QTL studies in which the phenotyping is more of a limiting factor than the generation of individuals and the scoring of genotypes, selective sampling is an attractive strategy for increasing genome-wide QTL map resolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.