ArticleGenetics2005
The structure and population genetics of the breakpoints associated with the cosmopolitan chromosomal inversion In(3R)Payne in Drosophila melanogaster.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- Article
- A Balanced Inversion Polymorphism Exhibits a Dominance Reversal at the Gene Expression Level that Depends on Developmental Context.Molecular biology and evolution · 2025Article
- Chromosomal Inversions in Chromosome U ofInsects · 2025Article
- The Influence of Chromosomal Inversions on Genetic Variation and Clinal Patterns in Genomic Data of Drosophila melanogaster.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Chromosomal Inversions and the Demography of Speciation in Drosophila montana and Drosophila flavomontana.Genome biology and evolution · 2024Article
- The relevance of chromatin architecture to genome rearrangements inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Extensive Recombination Suppression and Epistatic Selection Causes Chromosome-Wide Differentiation of a Selfish Sex Chromosome inGenetics · 2020Article
- The Cyclically SeasonalFrontiers in genetics · 2020Article
- The molecular genealogy of sequential overlapping inversions implies both homologous chromosomes of a heterokaryotype in an inversion origin.Scientific reports · 2019Article
- How chromosomal rearrangements shape adaptation and speciation: Case studies in Drosophila pseudoobscura and its sibling species Drosophila persimilis.Molecular ecology · 2019Article
- The molecular characterization of fixed inversions breakpoints unveils the ancestral character of the Drosophila guanche chromosomal arrangements.Scientific reports · 2019Article
- An inversion supergene in Drosophila underpins latitudinal clines in survival traits.Journal of evolutionary biology · 2018Article
- Muller "Elements" inGenetics · 2018Article
- Inversion evolutionary rates might limit the experimental identification of inversion breakpoints in non-model species.Scientific reports · 2017Article
- The Effect of Common Inversion PolymorphismsG3 (Bethesda, Md.) · 2017Article
- An easy route to the massive karyotyping of complex chromosomal arrangements in Drosophila.Scientific reports · 2017Article
- Multiple and diverse structural changes affect the breakpoint regions of polymorphic inversions across the Drosophila genus.Scientific reports · 2016Article
- The origin of chromosomal inversions as a source of segmental duplications in the Sophophora subgenus of Drosophila.Scientific reports · 2016Article
- Parallel effects of the inversion In(3R)Payne on body size across the North American and Australian clines in Drosophila melanogaster.Journal of evolutionary biology · 2016Article
- Putative adaptive inter-slope divergence of transposon frequency in fruit flies (Drosophila melanogaster) at "Evolution Canyon", Mount Carmel, Israel.Biology direct · 2015Article
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4 authors.
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Abstract
We report here the breakpoint structure and sequences of the Drosophila melanogaster cosmopolitan chromosomal inversion In(3R)P. Combining in situ hybridization to polytene chromosomes and long-range PCR, we have identified and sequenced the distal and proximal breakpoints. The breakpoints are not simple cut-and-paste structures; gene fragments and small duplications of DNA are associated with both breaks. The distal breakpoint breaks the tolkin (tok) gene and the proximal breakpoint breaks CG31279 and the tolloid (tld) gene. Functional copies of all three genes are found at the opposite breakpoints. We sequenced a representative sample of standard (St) and In(3R)P karyotypes for a 2-kb portion of the tok gene, as well as the same 2 kb from the pseudogene tok fragment found at the distal breakpoint of In(3R)P chromosomes. The tok gene in St arrangements possesses levels of polymorphism typical of D. melanogaster genes. The functional tok gene associated with In(3R)P shows little polymorphism. Numerous single-base changes, as well as deletions and duplications, are associated with the truncated copy of tok. The overall pattern of polymorphism is consistent with a recent origin of In(3R)P, on the order of Ne generations. The identification of these breakpoint sequences permits a simple PCR-based screen for In(3R)P.
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