ArticleGenetics2005
Characterization of active R2 retrotransposition in the rDNA locus of Drosophila simulans.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed.
- Review
- Conserved and divergent DNA recognition specificities and functions of R2 retrotransposon N-terminal domains.Cell reports · 2024Article
- The Dynamic Interplay Between Ribosomal DNA and Transposable Elements: A Perspective From Genomics and Cytogenetics.Molecular biology and evolution · 2024Article
- Article
- Integration, Regulation, and Long-Term Stability of R2 Retrotransposons.Microbiology spectrum · 2015Review
- Preferential occupancy of R2 retroelements on the B chromosomes of the grasshopper Eyprepocnemis plorans.PloS one · 2014Article
- A population genetic model for the maintenance of R2 retrotransposons in rRNA gene loci.PLoS genetics · 2013Article
- Y chromosome mediates ribosomal DNA silencing and modulates the chromatin state in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- R2 and R2/R1 hybrid non-autonomous retrotransposons derived by internal deletions of full-length elements.Mobile DNA · 2012Article
- Retrotransposition of R2 elements in somatic nuclei during the early development of Drosophila.Mobile DNA · 2011Article
- Independently derived targeting of 28S rDNA by A- and D-clade R2 retrotransposons: Plasticity of integration mechanism.Mobile genetic elements · 2011Article
- R2 dynamics in Triops cancriformis (Bosc, 1801) (Crustacea, Branchiopoda, Notostraca): turnover rate and 28S concerted evolution.Heredity · 2011Article
- The non-LTR retrotransposon R2 in termites (Insecta, Isoptera): characterization and dynamics.Journal of molecular evolution · 2011Article
- Article
- R2 retrotransposons encode a self-cleaving ribozyme for processing from an rRNA cotranscript.Molecular and cellular biology · 2010Article
- The pattern of R2 retrotransposon activity in natural populations of Drosophila simulans reflects the dynamic nature of the rDNA locus.PLoS genetics · 2009Article
- Origin of nascent lineages and the mechanisms used to prime second-strand DNA synthesis in the R1 and R2 retrotransposons of Drosophila.Genome biology · 2009Article
- The R2 mobile element of Rhynchosciara americana: molecular, cytological and dynamic aspects.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2009Article
- Role of recombination in the long-term retention of transposable elements in rRNA gene loci.Genetics · 2008Article
- Epigenetic regulation of retrotransposons within the nucleolus of Drosophila.Molecular and cellular biology · 2008Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The rRNA gene (rDNA) loci of all arthropod lineages contain non-LTR retrotransposable elements that have evolved to specifically insert into the 28S rRNA genes. Extensive in vitro experiments have been conducted to investigate the mechanism of R2 retrotransposition but little is known of the insertion frequency or cellular factors that might regulate R2 activity. In this article, isofemale lines obtained from a population of Drosophila simulans were surveyed for recent R2 insertions. Within most lines, all individuals showed the same collection of R2 insertions, providing no evidence for recent R2 activity. However, in a few of the isofemale lines, virtually all individuals differed in their R2 insertion profiles. The descendants of individual pairs of flies from these "active lines" rapidly accumulated new insertions. The frequent insertion of new R2 elements was associated with the elimination of old R2 elements from the rDNA locus. The existence of lines in which R2 retrotransposes frequently and lines in which the elements appear dormant suggests that cellular mechanisms that can regulate the activity of R2 exist. Retrotransposition activity was correlated with the number of full-length R2 elements but not with the size of the rDNA locus or the number of uninserted units.
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