ReviewThe Journal of experimental medicine2005
Signaling for NKT cell development: the SAP-FynT connection.
Review in The Journal of experimental medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 73 citations in OpenAlex.
- Artificial thymic organoid culture generates functional iPSC-derived CD4+ invariant natural killer T cells.Communications biology · 2026Article
- SLAMF receptors: key regulators of tumor progression and emerging targets for cancer immunotherapy.Molecular cancer · 2025Review
- Primordial Cells Bridging the Gap Between Innate and Adaptive Immunity.Advances in experimental medicine and biology · 2025Review
- Exploration of the role of immune cells and cell therapy in hepatocellular carcinoma.Frontiers in immunology · 2025Review
- Invariant natural killer T cells in lung diseases.Experimental & molecular medicine · 2023Review
- TRAF3IP3 at the trans-Golgi network regulates NKT2 maturation via the MEK/ERK signaling pathway.Cellular & molecular immunology · 2020Article
- Coexpression of YY1 Is Required to Elaborate the Effector Functions Controlled by PLZF in NKT Cells.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- The Role of Adaptor Proteins in the Biology of Natural Killer T (NKT) Cells.Frontiers in immunology · 2019Review
- Tissue-Resident Lymphocytes Across Innate and Adaptive Lineages.Frontiers in immunology · 2018Review
- Invariant natural killer T cells in hematopoietic stem cell transplantation: killer choice for natural suppression.Bone marrow transplantation · 2016Review
- Pak2 Controls Acquisition of NKT Cell Fate by Regulating Expression of the Transcription Factors PLZF and Egr2.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- The differential roles of mTOR, ERK, and JNK pathways in invariant natural killer T-cell function and survival.Inflammation · 2014Article
- Different subsets of natural killer T cells may vary in their roles in health and disease.Immunology · 2014Review
- SAP-Dependent and -Independent Regulation of Innate T Cell Development Involving SLAMF Receptors.Frontiers in immunology · 2014Article
- TNF receptor associated factor 3 plays a key role in development and function of invariant natural killer T cells.The Journal of experimental medicine · 2013Article
- SAP is required for the development of innate phenotype in H2-M3--restricted Cd8(+) T cells.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- NKT Cell Subsets Can Exert Opposing Effects in Autoimmunity, Tumor Surveillance and Inflammation.Current immunology reviews · 2012Article
- Review
- Article
- Transcription factor Bcl11b controls selection of invariant natural killer T-cells by regulating glycolipid presentation in double-positive thymocytes.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
New studies demonstrate a critical role for the adaptor protein SAP (SLAM-associated protein) during NKT cell development. By connecting homotypic SLAM family receptor interactions with the FynT Src kinase, SAP may integrate a set of long-standing yet seemingly disparate observations characterizing NKT cell development. In fact, SAP-dependent signaling may underlie the development of multiple unconventional T cell lineages whose thymic selection relies on homotypic interactions between hematopoietic cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.