ArticleGenome research2005
Disclosing hidden transcripts: mouse natural sense-antisense transcripts tend to be poly(A) negative and nuclear localized.
Article in Genome research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 141 citations in OpenAlex.
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- Transcriptome characterization of moso bamboo (Phyllostachys edulis) seedlings in response to exogenous gibberellin applications.BMC plant biology · 2018Article
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- LeishDB: a database of coding gene annotation and non-coding RNAs in Leishmania braziliensis.Database : the journal of biological databases and curation · 2017Article
- Detection of natural antisense non-coding RNAs transcribed fromBiomedical reports · 2015Article
- De novo Transcriptome Sequencing and Development of Abscission Zone-Specific Microarray as a New Molecular Tool for Analysis of Tomato Organ Abscission.Frontiers in plant science · 2015Article
- Development of genodynamic metrics for exploring the biophysics of DNA polymorphisms.Journal of computational biology and bioinformatics research · 2014Article
- The role of long non-coding RNAs in neurodevelopment, brain function and neurological disease.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Full-length enriched cDNA libraries and ORFeome analysis of sugarcane hybrid and ancestor genotypes.PloS one · 2014Article
- Gene expression profiling of sense and antisense transcripts in liver regeneration by microarray analysis.Biomedical reports · 2013Article
- Long noncoding RNAs are rarely translated in two human cell lines.Genome research · 2012Article
- Identification of sense and antisense transcripts regulated by drought in sugarcane.Plant molecular biology · 2012Article
- Transcriptional regulation of translocator protein (Tspo) via a SINE B2-mediated natural antisense transcript in MA-10 Leydig cells.Biology of reproduction · 2012Article
- Identification of potential antisense transcripts in rice using conventional microarray.Molecular biotechnology · 2012Article
- H19 antisense RNA can up-regulate Igf2 transcription by activation of a novel promoter in mouse myoblasts.PloS one · 2012Article
- Extensive relationship between antisense transcription and alternative splicing in the human genome.Genome research · 2011Article
- Convergent transcription confers a bistable switch in Enterococcus faecalis conjugation.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome-wide in silico analysis identified thousands of natural sense-antisense transcript (SAT) pairs in the mouse transcriptome. We investigated their expression using strand-specific oligo-microarray that distinguishes expression of sense and antisense RNA from 1947 SAT pairs. The majority of the predicted SATs are expressed at various steady-state levels in various tissues, and cluster analysis of the array data demonstrated that the ratio of sense and antisense expression for some of the SATs fluctuated markedly among these tissues, while the rest was unchanged. Surprisingly, further analyses indicated that vast amounts of multiple-sized transcripts are expressed from the SAT loci, which tended to be poly(A) negative, and nuclear localized. The tendency that the SATs are often not polyadenylated is conserved, even in the randomly chosen SAT genes in the plant Arabidopsis thaliana. Such common characteristics imply general roles of the SATs in regulation of gene expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.