ArticleBiological psychiatry2005
Behavioral heterogeneity in an animal model of neuropsychiatric lupus.
Article in Biological psychiatry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Endothelial Dysfunction: Insights into Systemic Lupus Erythematosus-associated Cardiovascular Disease and Neuropsychiatric Manifestations.Journal of cardiovascular translational research · 2026Review
- Article
- B cell and/or autoantibody deficiency do not prevent neuropsychiatric disease in murine systemic lupus erythematosus.Journal of neuroinflammation · 2016Article
- Diagnosis and early detection of CNS-SLE in MRL/lpr mice using peptide microarrays.BMC immunology · 2014Article
- Metabolic changes and DNA hypomethylation in cerebellum are associated with behavioral alterations in mice exposed to trichloroethylene postnatally.Toxicology and applied pharmacology · 2013Article
- Postnatal exposure to trichloroethylene alters glutathione redox homeostasis, methylation potential, and neurotrophin expression in the mouse hippocampus.Neurotoxicology · 2012Article
- The MRL/lpr mouse strain as a model for neuropsychiatric systemic lupus erythematosus.Journal of biomedicine & biotechnology · 2011Review
- Article
- Circulating brain-reactive autoantibodies and behavioral deficits in the MRL model of CNS lupus.Journal of neuroimmunology · 2010Article
- Disturbed distribution of proliferative brain cells during lupus-like disease.Brain, behavior, and immunity · 2009Article
- Proclivity to self-injurious behavior in MRL-lpr mice: implications for autoimmunity-induced damage in the dopaminergic system.Molecular psychiatry · 2008Article
- Genetic contributions to the autoantibody profile in a rabbit model of Systemic Lupus Erythematosus (SLE).Veterinary immunology and immunopathology · 2008Article
- Mouse behavioral mutants have neuroimaging abnormalities.Human brain mapping · 2007Article
- Neuroimmunopathology in a murine model of neuropsychiatric lupus.Brain research reviews · 2007Review
- Impaired response to amphetamine and neuronal degeneration in the nucleus accumbens of autoimmune MRL-lpr mice.Behavioural brain research · 2006Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundVarious psychiatric manifestations of unknown etiology are common in systemic autoimmune disease lupus erythematosus (SLE). Profound heterogeneity at clinical and neuropathological levels suggests distinct subpopulations of SLE patients and multiple mechanisms in the pathogenesis of aberrant behavior. Using inbred mice prone to SLE-like condition, we presently examine whether subpopulations of diseased mice can be identified on the basis of their behavioral performance.
methodsHierarchical cluster analysis was used to classify 105 MRL-lpr males into clusters. Multivariate analysis of variance (MANOVA) and discriminant function analysis were used to detect overall differences and identify discriminative variables.
resultsCluster 1 was characterized by blunted responsiveness to palatable stimulation, as well as increased spleen mass and serum levels of interleukin-1. Cluster 2 comprised of animals with reduced ambulation speed and enlarged spleen. Mice from cluster 3 showed profound dilatation of brain ventricles, reduced brain mass, impaired nutrition and performance in task reflective of emotional reactivity.
conclusionsPresent results suggest that systemic autoimmunity compromises brain function via non-Mendelian mechanisms. Although neuroactive cytokines may impair reward systems, brain atrophy seems to underlie deficits in ingestive behavior and emotional reactivity. This study supports the hypothesis that multiple neuroimmunological pathways are involved in the etiology of aberrant behavior during SLE-like disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.