ArticleBrain pathology (Zurich, Switzerland)2005
Genes associated with fast glioma cell migration in vitro and in vivo.
Article in Brain pathology (Zurich, Switzerland), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 36 citations in OpenAlex.
- Review
- A composite network of conserved and tissue specific gene interactions reveals possible genetic interactions in glioma.PLoS computational biology · 2017Article
- Id4 suppresses MMP2-mediated invasion of glioblastoma-derived cells by direct inactivation of Twist1 function.Oncogene · 2015Article
- Imaging the microanatomy of astrocyte-T-cell interactions in immune-mediated inflammation.Frontiers in cellular neuroscience · 2013Article
- The impact of phenotypic switching on glioblastoma growth and invasion.PLoS computational biology · 2012Article
- A coculture assay to visualize and monitor interactions between migrating glioma cells and nerve fibers.Nature protocols · 2009Article
- The proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motility.The Journal of biological chemistry · 2008Article
- Metastatic osteosarcoma gene expression differs in vitro and in vivo.Clinical orthopaedics and related research · 2008Article
- Phenotypic and genotypic characterization of orthotopic human glioma models and its relevance for the study of anti-glioma therapy.Brain pathology (Zurich, Switzerland) · 2008Article
- Prevention of human PC-346C prostate cancer growth in mice by a xenogeneic tissue vaccine.Cancer immunology, immunotherapy : CII · 2007Article
- Systematic analysis of the transcriptional switch inducing migration of border cells.Developmental cell · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Identification of genes mediating glioma invasion promotes the understanding of glia motility and might result in biologically based therapeutic approaches. Most experimental studies have been performed in vitro, although glial cells typically undergo marked phenotypic change following placement into cell culture. To evaluate migration mechanisms operating in vitro versus in vivo, we used C6 rat glioblastoma cells for selecting highly migratory cells in a monolayer migration assay as well as in brains of nude mice, and analyzed in each paradigm the expression profiles of these "fast" cells versus those of the original "slow" cells using oligonucleotide microarrays comprising 8832 genes. In vitro, 516 (10.6%) of 4848 expressed genes were regulated (i.e., differentially expressed in fast versus slow cells); 916 genes were expressed only in vitro, including 142 (15.5%) regulated genes. In vivo, 245 (6.1%) of 4044 expressed genes were regulated; 112 genes were expressed only in vivo, including 25 (22.3%) regulated genes, none of them having a known relation to glioma invasion. Of 730 regulated genes, only 31 (4.2%) were regulated in parallel in vitro and in vivo, most of them having a known relation to (glioma) invasion. Our data provide new molecular entry points for identifying glioma invasion genes operating exclusively in the brain. They further suggest that genes underlying glia cell motility are strikingly different in vitro and in vivo.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.