ArticlePsychopharmacology2005
Somatostatin receptors in the ventral pallidum/substantia innominata modulate rat locomotor activity.
Article in Psychopharmacology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- Immunoregulatory role of hesperidin against ovalbumin (OVA)-induced bronchial asthma and depression in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Characterization of the somatostatin system in tilapia: implications for growth and reproduction.Frontiers in endocrinology · 2024Article
- Somatostatin-28 modulates prepulse inhibition of the acoustic startle response, reward processes and spontaneous locomotor activity in rats.Neuropeptides · 2010Article
- Anxiolytic and antidepressant actions of somatostatin: the role of sst2 and sst3 receptors.Psychopharmacology · 2009Article
- Somatostatin increases rat locomotor activity by activating sst(2) and sst (4) receptors in the striatum and via glutamatergic involvement.Naunyn-Schmiedeberg's archives of pharmacology · 2009Article
- Activation of somatostatin receptors in the globus pallidus increases rat locomotor activity and dopamine release in the striatum.Psychopharmacology · 2008Article
- Predator stress induces behavioral inhibition and amygdala somatostatin receptor 2 gene expression.Genes, brain, and behavior · 2008Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleSomatostatin and its receptors (sst(1) and sst(2)) have been localized in brain nuclei implicated in motor control, such as the nucleus accumbens, ventral pallidum (VP) and substantia innominata (SI).
objectivesThe objective of the study is to investigate the effect of somatostatin and selective sst(1) and sst(2) analogs infused in the VP/SI on the locomotor activity of the rat.
methodsSomatostatin (15, 30, 60, 120 and 240 ng/0.5 microl/side), CH275 (sst(1) analog; 60, 180, 240 and 480 ng/0.5 microl/side), MK678 (sst(2) analog; 120, 240 and 480 ng/0.5 microl/side), L-809,087 (sst(4) agonist, 240 ng/0.5 microl/side) or saline (vehicle) were infused bilaterally in the VP/SI of the rat and locomotor activity measured for 60 min. The effect of SRA-880 (sst(1) antagonist) and CYN-154806 (sst(2) antagonist) on somatostatin-, CH275- and MK678-mediated locomotor activity was also ascertained.
resultsSomatostatin decreased locomotor activity in the first 30 min after its infusion in the VP/SI and in a dose-dependent manner. The sst(1) and sst(2) antagonists, SRA-880 and CYN-154806, respectively, reversed the somatostatin effect. The sst(1) and sst(2) agonists CH275 and MK678, respectively, mimicked somatostatin's actions, while the selective sst(4) agonist L-809,087 had no effect. Moreover, SRA-880 and CYN-154806 reversed the respective agonist action on locomotor activity.
conclusionThe present study provides functional evidence for the presence of sst(1) and sst(2) receptors in the VP/SI and their implication in motor control. The mechanism via which somatostatin and agonists mediate the attenuation of locomotor activity is presently being investigated.
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