ArticleVirchows Archiv : an international journal of pathology2005
Changes in the adherens junctions of human endothelial cells infected with spotted fever group rickettsiae.
Article in Virchows Archiv : an international journal of pathology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- Rickettsia conorii infection with fatal complication.Autopsy & case reports · 2022Article
- RevisitingMicroorganisms · 2021Article
- Spotted fever rickettsiosis presenting with bilateral anterior uveitis and retinitis: A case report.Journal of family medicine and primary care · 2020Article
- The Many Faces of Bacterium-Endothelium Interactions during Systemic Infections.Microbiology spectrum · 2019Review
- Pathogenesis of Rickettsial Diseases: Pathogenic and Immune Mechanisms of an Endotheliotropic Infection.Annual review of pathology · 2019Review
- A Concise Review of the Epidemiology and Diagnostics of Rickettsioses: Rickettsia and Orientia spp.Journal of clinical microbiology · 2018Review
- In vitro studies of Rickettsia-host cell interactions: Confocal laser scanning microscopy of Rickettsia helvetica-infected eukaryotic cell lines.PLoS neglected tropical diseases · 2018Article
- Routine argyrophil techniques detectJournal of histotechnology · 2016Article
- Endothelial Cell Proteomic Response to Rickettsia conorii Infection Reveals Activation of the Janus Kinase (JAK)-Signal Transducer and Activator of Transcription (STAT)-Inferferon Stimulated Gene (ISG)15 Pathway and Reprogramming Plasma Membrane Integrin/Cadherin Signaling.Molecular & cellular proteomics : MCP · 2016Article
- OmpA-mediated rickettsial adherence to and invasion of human endothelial cells is dependent upon interaction with α2β1 integrin.Cellular microbiology · 2013Article
- Rickettsiae induce microvascular hyperpermeability via phosphorylation of VE-cadherins: evidence from atomic force microscopy and biochemical studies.PLoS neglected tropical diseases · 2012Article
- New insight into immunity and immunopathology of Rickettsial diseases.Clinical & developmental immunology · 2012Review
- Infection of the endothelium by members of the order Rickettsiales.Thrombosis and haemostasis · 2009Review
- Host-cell interactions with pathogenic Rickettsia species.Future microbiology · 2009Review
- Host defenses to Rickettsia rickettsii infection contribute to increased microvascular permeability in human cerebral endothelial cells.Journal of clinical immunology · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Rickettsiae of the spotted fever group are obligately intracellular bacteria that primarily infect the vascular endothelium, invade adjacent cells propelled by actin polymerization, and cause severe systemic diseases. Endothelial dysfunction and vascular leakage develop as a consequence; this effect is the pathophysiological mechanism that explains most clinical manifestations. Here we report that rickettsial infection of cultured primary human endothelial cells is associated with the formation of gaps in the interendothelial adherens junctions, occurring late during the course of in vitro infections but not early, even when rickettsial loads are significant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.