ArticleThe Journal of cell biology1992
Neurolin, a cell surface glycoprotein on growing retinal axons in the goldfish visual system, is reexpressed during retinal axonal regeneration.
Article in The Journal of cell biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 81 citations in OpenAlex.
- Identification and enrichment of human retinal organoid-derived red/green cone-competent precursors with enhanced axon dynamics.Stem cell research & therapy · 2026Article
- zRICH, a protein induced during optic nerve regeneration in zebrafish, promotes neuritogenesis and interacts with tubulin.Brain research · 2012Article
- Gene expression profiling of Atlantic cod (Gadus morhua) embryogenesis using microarray.Marine biotechnology (New York, N.Y.) · 2012Article
- Mechanisms of transcriptional regulation and prognostic significance of activated leukocyte cell adhesion molecule in cancer.Molecular cancer · 2010Article
- Activated leukocyte cell adhesion molecule in breast cancer: prognostic indicator.Breast cancer research : BCR · 2004Article
- Mesenchymal stem cells in perichondrium express activated leukocyte cell adhesion molecule and participate in bone marrow formation.The Journal of experimental medicine · 2002Article
- A purine-sensitive pathway regulates multiple genes involved in axon regeneration in goldfish retinal ganglion cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Neurolin Ig domain 2 participates in retinal axon guidance and Ig domains 1 and 3 in fasciculation.The Journal of cell biology · 1999Article
- Neurolin, the goldfish homolog of DM-GRASP, is involved in retinal axon pathfinding to the optic disk.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- BEN/SC1/DM-GRASP, a homophilic adhesion molecule, is required for in vitro myeloid colony formation by avian hemopoietic progenitors.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Fish E587 glycoprotein, a member of the L1 family of cell adhesion molecules, participates in axonal fasciculation and the age-related order of ganglion cell axons in the goldfish retina.The Journal of cell biology · 1995Article
- Developmental expression of KG-CAM in the rat neostriatum.Anatomy and embryology · 1995Article
- ALCAM: Basis Sequence: Mouse.The AFCS-nature molecule pagesArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mAb E 21 recognizes a cell surface glycoprotein selectively associated with fish retinal ganglion cell axons that are in a state of growth. All retinal axons and ganglion cells in goldfish embryos stained for E 21. In adult fish, however, E 21 immunoreactivity exhibited a patterned distribution in ganglion cells in the marginal growth zone of the continuously enlarging fish retina and the new axons emerging from these cells in the retina, optic nerve, and optic tract. The E 21 antigen was absent from older axons, except the terminal arbor layer in the tectum, the Stratum fibrosum et griseum superficiale where it was uniformly distributed. Upon optic nerve transection, the previously unlabeled axons reacquired E 21 positivity as they regenerated throughout their path to the tectum. Several months after ONS, however, E 21 staining disappeared from the regenerated axons over most of their lengths but reappeared as in normal fish in the terminal arbor layer. The immunoaffinity-purified E 21 antigen, called Neurolin, has an apparent molecular mass of 86 kD and contains the HNK1/L2 carbohydrate moiety, like several members of the class of cell adhesion molecules of the Ig superfamily. The NH2-terminal amino acid sequence has homologies to the cell adhesion molecule DM-Grasp recently described in the chicken. Thus, retinal ganglion cell axons express Neurolin during their development and are able to reexpress this candidate cell adhesion molecule during axonal regeneration, suggesting that Neurolin is functionally important for fish retinal axon growth.
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