ArticleThe Journal of cell biology1992
Meiosis, egg activation, and nuclear envelope breakdown are differentially reliant on Ca2+, whereas germinal vesicle breakdown is Ca2+ independent in the mouse oocyte.
Article in The Journal of cell biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 242 citations in OpenAlex.
- Mitochondria-ER contact sites expand during mitosis.iScience · 2024Article
- Calcium signaling in oocyte quality and functionality and its application.Frontiers in endocrinology · 2024Review
- Article
- Neurotransmitters, neuropeptides and calcium in oocyte maturation and early development.Frontiers in cell and developmental biology · 2022Review
- Lipid Signaling During Gamete Maturation.Frontiers in cell and developmental biology · 2022Review
- Dynamic shapes of the zygote and two-cell mouse and human.Biology open · 2021Article
- Modulators of calcium signalling at fertilization.Open biology · 2020Review
- Divalent cation influx and calcium homeostasis in germinal vesicle mouse oocytes.Cell calcium · 2020Article
- Mouse strain-dependent egg factors regulate calcium signals at fertilization.Molecular reproduction and development · 2020Article
- Remodeling of ER-plasma membrane contact sites but not STIM1 phosphorylation inhibits CaProceedings of the National Academy of Sciences of the United States of America · 2019Article
- TRPM7 and CaProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Spindle function in Xenopus oocytes involves possible nanodomain calcium signaling.Molecular biology of the cell · 2016Article
- TRPM7-like channels are functionally expressed in oocytes and modulate post-fertilization embryo development in mouse.Scientific reports · 2016Article
- CaV3.2 T-type channels mediate Ca²⁺ entry during oocyte maturation and following fertilization.Journal of cell science · 2015Article
- Regulator of G-protein signaling 2 (RGS2) suppresses premature calcium release in mouse eggs.Development (Cambridge, England) · 2015Article
- Z-scan fluorescence profile deconvolution of cytosolic and membrane-associated protein populations.Analytical biochemistry · 2015Article
- The role of MATER in endoplasmic reticulum distribution and calcium homeostasis in mouse oocytes.Developmental biology · 2014Article
- TRPV3 channels mediate strontium-induced mouse-egg activation.Cell reports · 2013Article
- Prophase I mouse oocytes are deficient in the ability to respond to fertilization by decreasing membrane receptivity to sperm and establishing a membrane block to polyspermy.Biology of reproduction · 2013Article
- Ca2+ influx and the store-operated Ca2+ entry pathway undergo regulation during mouse oocyte maturation.Molecular biology of the cell · 2013Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
During early development, intracellular Ca2+ mobilization is not only essential for fertilization, but has also been implicated during other meiotic and mitotic events, such as germinal vesicle breakdown (GVBD) and nuclear envelope breakdown (NEBD). In this study, the roles of intracellular and extracellular Ca2+ were examined during meiotic maturation and reinitiation at parthenogenetic activation and during first mitosis in a single species using the same methodologies. Cumulus-free metaphase II mouse oocytes immediately resumed anaphase upon the induction of a large, transient Ca2+ elevation. This resumption of meiosis and associated events, such as cortical granule discharge, were not sensitive to extracellular Ca2+ removal, but were blocked by intracellular Ca2+ chelators. In contrast, meiosis I was dependent on external Ca2+; in its absence, the formation and function of the first meiotic spindle was delayed, the first polar body did not form and an interphase-like state was induced. GVBD was not dependent on external Ca2+ and showed no associated Ca2+ changes. NEBD at first mitosis in fertilized eggs, on the other hand, was frequently, but not always associated with a brief Ca2+ transient and was dependent on Ca2+ mobilization. We conclude that GVBD is Ca2+ independent, but that the dependence of NEBD on Ca2+ suggests regulation by more than one pathway. As cells develop from Ca(2+)-independent germinal vesicle oocytes to internal Ca(2+)-dependent pronuclear eggs, internal Ca2+ pools increase by approximately fourfold.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.