ReviewImmunologic research2005
Metabolic mechanisms of tumor resistance to T cell effector function.
Review in Immunologic research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Signaling pathways and targeted therapies in lung squamous cell carcinoma: mechanisms and clinical trials.Signal transduction and targeted therapy · 2022Review
- IL-36β Promotes CD8Frontiers in immunology · 2019Article
- An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression.Cancer cell · 2017Article
- Filling the Tank: Keeping Antitumor T Cells Metabolically Fit for the Long Haul.Cancer immunology research · 2016Review
- mTORC1-dependent metabolic reprogramming is a prerequisite for NK cell effector function.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Ways to enhance lymphocyte trafficking into tumors and fitness of tumor infiltrating lymphocytes.Frontiers in oncology · 2013Review
- [The systemic evaluation and clinical significance of immunological function for advanced lung cancer patients].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2010Article
- Current approaches in dendritic cell generation and future implications for cancer immunotherapy.Cancer immunology, immunotherapy : CII · 2007Review
- Combination of physical activity, nutrition, or other metabolic factors and vaccine response.Frontiers in bioscience : a journal and virtual library · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Established tumors develop ways to elude destruction by the host immune system. Recent work has revealed that tumors can take advantage of the generation of metabolic dysregulation to inhibit immune responses. Effector T-cell functions are particularly sensitive to nutrient availability in the tumor microenvironment. In this review, we highlight experimental data supporting the importance of glucose, oxygen, tryptophan, and arginine for optimal T-cell function, and the mechanisms by which these nutrients may become depleted in the tumor microenvironment. These observations provide a conceptual framework for modulating metabolic features of the T cell-tumor interaction, toward the end of promoting more effective immune-mediated tumor destruction in vivo.
Indexed as
Identifiers
15778509What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.