ArticleNucleic acids research2005
Two modes of microsatellite instability in human cancer: differential connection of defective DNA mismatch repair to dinucleotide repeat instability.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 68 citations in OpenAlex.
- More subtle microsatellite instability better predicts fluorouracil insensitivity in colorectal cancer patients.Scientific reports · 2024Article
- HTLV-1 bZIP factor impairs DNA mismatch repair system.Biochemical and biophysical research communications · 2023Article
- Microsatellite Instability: From the Implementation of the Detection to a Prognostic and Predictive Role in Cancers.International journal of molecular sciences · 2022Review
- MutL homolog 1 methylation and microsatellite instability in sporadic colorectal tumors among Filipinos.World journal of gastrointestinal oncology · 2021Article
- Germline Risk Contribution to Genomic Instability in Multiple Myeloma.Frontiers in genetics · 2019Review
- Fluorescence detection of DNA mismatch repair in human cells.Scientific reports · 2018Article
- A specific mode of microsatellite instability is a crucial biomarker in adult T-cell leukaemia/lymphoma patients.Journal of cancer research and clinical oncology · 2017Article
- Modal variety of microsatellite instability in human endometrial carcinomas.Journal of cancer research and clinical oncology · 2016Article
- MSH3 polymorphisms and protein levels affect CAG repeat instability in Huntington's disease mice.PLoS genetics · 2013Article
- Implication of microsatellite instability in human gastric cancers.The Indian journal of medical research · 2012Review
- Fusion tyrosine kinase NPM-ALK Deregulates MSH2 and suppresses DNA mismatch repair function novel insights into a potent oncoprotein.The American journal of pathology · 2011Article
- Concurrent genetic alterations in DNA polymerase proofreading and mismatch repair in human colorectal cancer.European journal of human genetics : EJHG · 2011Article
- Article
- Microsatellite instability in pediatric high grade glioma is associated with genomic profile and differential target gene inactivation.PloS one · 2011Article
- The Mutyh base excision repair gene influences the inflammatory response in a mouse model of ulcerative colitis.PloS one · 2010Article
- Type A microsatellite instability in pediatric gliomas as an indicator of Turcot syndrome.European journal of human genetics : EJHG · 2009Article
- The prevalence of microsatellite instability in head and neck squamous cell carcinoma.Journal of cancer research and clinical oncology · 2009Article
- DNA repair dysfunction in gastrointestinal tract cancers.Cancer science · 2008Review
- The genome-wide determinants of human and chimpanzee microsatellite evolution.Genome research · 2008Article
- Involvement of mismatch repair in transcription-coupled nucleotide excision repair.Human cell · 2005Review
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Authors and funding
19 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microsatellite instability (MSI) is associated with defective DNA mismatch repair in various human malignancies. Using a unique fluorescent technique, we have observed two distinct modes of dinucleotide microsatellite alterations in human colorectal cancer. Type A alterations are defined as length changes of < or =6 bp. Type B changes are more drastic and involve modifications of > or =8 bp. We show here that defective mismatch repair is necessary and sufficient for Type A changes. These changes were observed in cell lines and in tumours from mismatch repair gene-knockout mice. No Type B instability was seen in these cells or tumours. In a panel of human colorectal tumours, both Type A MSI and Type B instability were observed. Both types of MSI were associated with hMSH2 or hMLH1 mismatch repair gene alterations. Intriguingly, p53 mutations, which are generally regarded as uncommon in human tumours of the MSI+ phenotype, were frequently associated with Type A instability, whereas none was found in tumours with Type B instability, reflecting the prevailing viewpoint. Inspection of published data reveals that the microsatellite instability that has been observed in various malignancies, including those associated with Hereditary Non-Polyposis Colorectal Cancer (HNPCC), is predominantly Type B. Our findings indicate that Type B instability is not a simple reflection of a repair defect. We suggest that there are at least two qualitatively distinct modes of dinucleotide MSI in human colorectal cancer, and that different molecular mechanisms may underlie these modes of MSI. The relationship between MSI and defective mismatch repair may be more complex than hitherto suspected.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.