ArticleProceedings of the National Academy of Sciences of the United States of America2005
An initial strategy for the systematic identification of functional elements in the human genome by low-redundancy comparative sequencing.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 118 citations in OpenAlex.
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- Comparative genomic analysis of eutherian fibroblast growth factor genes.BMC genomics · 2020Article
- Comparative genomic analysis of eutherian connexin genes.Scientific reports · 2019Article
- Functional conservation of sequence determinants at rapidly evolving regulatory regions across mammals.PLoS computational biology · 2018Article
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- Comparative genomic analysis of eutherian kallikrein genes.Molecular genetics and metabolism reports · 2017Article
- Next generation sequencing technology and genomewide data analysis: Perspectives for retinal research.Progress in retinal and eye research · 2016Review
- Curated eutherian third party data gene data sets.Data in brief · 2016Article
- Third party data gene data set of eutherian growth hormone genes.Genomics data · 2015Article
- Initial description of primate-specific cystine-knot Prometheus genes and differential gene expansions of D-dopachrome tautomerase genes.Meta gene · 2015Article
- Third party annotation gene data set of eutherian lysozyme genes.Genomics data · 2014Article
- Comparative genomic analysis of eutherian ribonuclease A genes.Molecular genetics and genomics : MGG · 2014Article
- Sequencing depth and coverage: key considerations in genomic analyses.Nature reviews. Genetics · 2014Review
- Comparative genomic analysis of eutherian interferon-γ-inducible GTPases.Functional & integrative genomics · 2012Review
- Statistical approaches to use a model organism for regulatory sequences annotation of newly sequenced species.PloS one · 2012Article
- Predicting site-specific human selective pressure using evolutionary signatures.Bioinformatics (Oxford, England) · 2011Article
- Article
- Estimating allele frequency from next-generation sequencing of pooled mitochondrial DNA samples.Frontiers in genetics · 2011Article
- Five-vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor binding.Science (New York, N.Y.) · 2010Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
With the recent completion of a high-quality sequence of the human genome, the challenge is now to understand the functional elements that it encodes. Comparative genomic analysis offers a powerful approach for finding such elements by identifying sequences that have been highly conserved during evolution. Here, we propose an initial strategy for detecting such regions by generating low-redundancy sequence from a collection of 16 eutherian mammals, beyond the 7 for which genome sequence data are already available. We show that such sequence can be accurately aligned to the human genome and used to identify most of the highly conserved regions. Although not a long-term substitute for generating high-quality genomic sequences from many mammalian species, this strategy represents a practical initial approach for rapidly annotating the most evolutionarily conserved sequences in the human genome, providing a key resource for the systematic study of human genome function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.