ArticleAnnals of the rheumatic diseases2005
Close association between valvar heart disease and central nervous system manifestations in the antiphospholipid syndrome.
Article in Annals of the rheumatic diseases, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 74 citations in OpenAlex.
- Development of 2023 ACR/EULAR Antiphospholipid Syndrome Classification Criteria, Phase III-A/B Report: Defining and Structuring the Clinical and Laboratory Domains.Current rheumatology reports · 2025Review
- Recurrent embolic strokes due to antiphospholipid syndrome and non-bacterial thrombotic endocarditis in a patient with basal cell carcinoma.Journal of cardiothoracic surgery · 2023Article
- Heart Valve Involvement in Patients with Antiphospholipid Syndrome: A Long-Term Follow-Up Study of a Single Centre.Journal of clinical medicine · 2023Article
- Combined brain/heart magnetic resonance imaging in antiphospholipid syndrome-two sides of the same coin.Clinical rheumatology · 2021Review
- Definition and treatment approach of non-criteria clinical manifestations of antiphospholipid syndrome.European journal of rheumatology · 2020Article
- A high-risk laboratory profile of antiphospholipid antibodies and thrombosis is associated with a large number of extra-criteria manifestations in obstetric antiphospholipid syndrome.Immunologic research · 2019Article
- Libman-Sacks endocarditis in patients with systemic lupus erythematosus with secondary antiphospholipid syndrome.Caspian journal of internal medicine · 2019Article
- Cardiac Manifestations of Antiphospholipid Syndrome With Focus on Its Primary Form.Frontiers in immunology · 2019Review
- Nonbacterial thrombotic endocarditis in a patient with primary antiphospholipid syndrome.Oxford medical case reports · 2018Article
- Complete Resolution of a Large Bicuspid Aortic Valve Thrombus with Anticoagulation in Primary Antiphospholipid Syndrome.Frontiers in cardiovascular medicine · 2017Article
- The Migraine-Stroke Connection.Journal of stroke · 2016Review
- Non-stroke Central Neurologic Manifestations in Antiphospholipid Syndrome.Current rheumatology reports · 2016Review
- Valvular heart disease in antiphospholipid syndrome.Current rheumatology reports · 2013Review
- Association of annular calcification and aortic valve sclerosis with brain findings on magnetic resonance imaging in community dwelling older adults: the cardiovascular health study.Journal of the American College of Cardiology · 2011Article
- Article
- Neurologic manifestations of the antiphospholipid syndrome: integrating molecular and clinical lessons.Current rheumatology reports · 2008Review
- The Heart and APS.Clinical reviews in allergy & immunology · 2007Review
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHeart valves lesions and central nervous system involvement are among the most common manifestations of the antiphospholipid syndrome (APS).
objectiveTo evaluate possible interrelations between these manifestations in a large group of APS patients.
methods284 APS patients were evaluated retrospectively, 159 of whom had primary APS. Cardiac-CNS associations were determined for the entire study population, and for subgroups of patients with primary APS or APS associated with systemic lupus erythematosus (SLE).
resultsSignificant associations where found between cardiac vegetations and epilepsy (p < 0.02), and between cardiac valve thickening or dysfunction and migraine (p = 0.002). Borderline association was found between valvar vegetations and migraine (p = 0.09). A significant association was also found between all valvar lesions and stroke or transient ischaemic attacks. Subanalyses showed that patients with primary APS had significant associations between cardiac valve pathology and all CNS manifestations, while patients with APS associated with SLE had no such associations.
conclusionsThe study suggests potential differences in biological behaviour between primary APS and APS associated with SLE. The presence of cardiac valve pathology may be a risk factor for several types of CNS involvement in PAPS.
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