ArticleJournal of molecular medicine (Berlin, Germany)2005
An autosomal genomic scan for loci linked to type 2 diabetes in northern Han Chinese.
Article in Journal of molecular medicine (Berlin, Germany), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of 23 type 2 diabetes linkage studies from the International Type 2 Diabetes Linkage Analysis Consortium.Human heredity · 2008Pooled it
- A Common Polymorphism of Upstream Transcription Factor 1 Gene is associated with Lipid Profile: A Study in Chinese Type 2 Diabetes Families.International journal of biomedical science : IJBS · 2009Article
- Agreement among type 2 diabetes linkage studies but a poor correlation with results from genome-wide association studies.Diabetologia · 2009Article
- Suggestion for linkage of chromosome 1p35.2 and 3q28 to plasma adiponectin concentrations in the GOLDN Study.BMC medical genetics · 2009Article
- Lack of association between PKLR rs3020781 and NOS1AP rs7538490 and type 2 diabetes, overweight, obesity and related metabolic phenotypes in a Danish large-scale study: case-control studies and analyses of quantitative traits.BMC medical genetics · 2008Article
- Association between urokinase haplotypes and outcome from infection-associated acute lung injury.Intensive care medicine · 2008Article
- Analysis of phenotype-genotype connection: the story of dissecting disease pathogenesis in genomic era in China, and beyond.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2007Review
- The search for type 2 diabetes susceptibility loci: the chromosome 1q story.Current diabetes reports · 2007Review
- Article
- Association study of genetic polymorphisms of SLC2A10 gene and type 2 diabetes in the Taiwanese population.Diabetologia · 2006Article
Corrections and comments
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Authors and funding
19 authors.
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Abstract
We report the results of a genome-wide scan conducted in 219 individuals from 34 large multiplex nuclear pedigrees from the northern Han Chinese population at an average resolution of about 10 cM. Nonparametric two-point and multipoint linkage analyses were performed to detect evidence of linkage with type 2 diabetes in this study. On chromosome 1 four regions showed evidence of linkage with type 2 diabetes in northern Han Chinese. Of these regions a marker D1S193 (73 cM) showed evidence of linkage (two-point nonparametric linkage 2.409), and another region (around 190 cM) was a replication of several other studies performed in different ethnic populations. Evidences of linkage have been confirmed by typing additional markers (average distance 1-5 cM) flanking these two positive regions on chromosome 1. We also found indication of linkage with type 2 diabetes on chromosomes 2, 10, 12, 18, 20, and 22 by two-point linkage analyses.
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Registered trials
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