ArticleThe Journal of clinical investigation2005
Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury.
Article in The Journal of clinical investigation, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
65 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of iNOS in Hepatic Warm Ischaemia and Reperfusion Models in Mice and Rats: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2022Pooled it
- Cardiac preservation usingFrontiers in cardiovascular medicine · 2025Article
- Implications of neonatal absence of innate immune mediated NFκB/AP1 signaling in the murine liver.Pediatric research · 2024Article
- DA-6034 ameliorates hepatic steatosis and inflammation in high fat diet-induced obese mice.Journal of Yeungnam medical science · 2024Article
- Current investigations for liver fibrosis treatment: between repurposing the FDA-approved drugs and the other emerging approaches.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2023Review
- Molecular Mechanisms of Ischaemia-Reperfusion Injury and Regeneration in the Liver-Shock and Surgery-Associated Changes.International journal of molecular sciences · 2022Review
- IKKα plays a major role in canonical NF-κB signalling in colorectal cells.The Biochemical journal · 2022Article
- Intravenous immunoglobulin is effective in alleviating hepatic ischemia-reperfusion injury: a rat model study.Molecular biology reports · 2022Article
- How Machine Perfusion Ameliorates Hepatic Ischaemia Reperfusion Injury.International journal of molecular sciences · 2021Review
- Anti-fibrotic treatments for chronic liver diseases: The present and the future.Clinical and molecular hepatology · 2021Review
- Relevance of SIRT1-NF-κB Axis as Therapeutic Target to Ameliorate Inflammation in Liver Disease.International journal of molecular sciences · 2020Review
- Therapeutics administered duringWorld journal of transplantation · 2020Review
- Signal Transduction for TNFα-Induced Type II SOCS Expression and Its Functional Implication in Growth Hormone Resistance in Carp Hepatocytes.Frontiers in endocrinology · 2020Article
- NF-κB RelA Is Required for Hepatoprotection during Pneumonia and Sepsis.Infection and immunity · 2019Article
- Article
- Cell Type-Specific Roles of NF-κB Linking Inflammation and Thrombosis.Frontiers in immunology · 2019Review
- Neutralization of CD95 ligand protects the liver against ischemia-reperfusion injury and prevents acute liver failure.Cell death & disease · 2018Article
- Hepatic Ischemia/Reperfusion: Mechanisms of Tissue Injury, Repair, and Regeneration.Gene expression · 2017Review
- Nuclear Receptor PPARα Agonist Wy-14,643 Ameliorates Hepatic Cell Death in Hepatic IKKβ-Deficient Mice.Biomolecules & therapeutics · 2017Article
- mTOR activation protects liver from ischemia/reperfusion-induced injury through NF-κB pathway.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
5 more citing papers are in PubMed but not listed here.
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11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The inhibitor of NF-kappaB (I-kappaB) kinase (IKK) complex consists of 3 subunits, IKK1, IKK2, and NF-kappaB essential modulator (NEMO), and is involved in the activation of NF-kappaB by various stimuli. IKK2 or NEMO constitutive knockout mice die during embryogenesis as a result of massive hepatic apoptosis. Therefore, we examined the role of IKK2 in TNF-induced apoptosis and ischemia/reperfusion (I/R) injury in the liver by using conditional knockout mice. Hepatocyte-specific ablation of IKK2 did not lead to impaired activation of NF-kappaB or increased apoptosis after TNF-alpha stimulation whereas conditional NEMO knockout resulted in complete block of NF-kappaB activation and massive hepatocyte apoptosis. In a model of partial hepatic I/R injury, mice lacking IKK2 in hepatocytes displayed significantly reduced liver necrosis and inflammation than wild-type mice. AS602868, a novel chemical inhibitor of IKK2, protected mice from liver injury due to I/R without sensitizing them toward TNF-induced apoptosis and could therefore emerge as a new pharmacological therapy for liver resection, hemorrhagic shock, or transplantation surgery.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.