ArticleThe EMBO journal2005
Gamma-BAR, a novel AP-1-interacting protein involved in post-Golgi trafficking.
Article in The EMBO journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 45 citations in OpenAlex.
- The role of the AP-1 adaptor complex in outgoing and incoming membrane traffic.The Journal of cell biology · 2024Article
- Cellular and pathophysiological consequences of Arp2/3 complex inhibition: role of inhibitory proteins and pharmacological compounds.Cellular and molecular life sciences : CMLS · 2019Review
- Article
- Contributions of epsinR and gadkin to clathrin-mediated intracellular trafficking.Molecular biology of the cell · 2015Article
- Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Role of AP1 and Gadkin in the traffic of secretory endo-lysosomes.Molecular biology of the cell · 2011Article
- CC chemokine receptor 5 (CCR5) desensitization: cycling receptors accumulate in the trans-Golgi network.The Journal of biological chemistry · 2010Article
- Gadkin: A novel link between endosomal vesicles and microtubule tracks.Communicative & integrative biology · 2010Article
- A novel subtype of AP-1-binding motif within the palmitoylated trans-Golgi network/endosomal accessory protein Gadkin/gamma-BAR.The Journal of biological chemistry · 2010Article
- Regulation of endosomal membrane traffic by a Gadkin/AP-1/kinesin KIF5 complex.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Eps15 mediates vesicle trafficking from the trans-Golgi network via an interaction with the clathrin adaptor AP-1.Molecular biology of the cell · 2008Article
- Structure of the Eps15-stonin2 complex provides a molecular explanation for EH-domain ligand specificity.The EMBO journal · 2008Article
- The trans-Golgi network accessory protein p56 promotes long-range movement of GGA/clathrin-containing transport carriers and lysosomal enzyme sorting.Molecular biology of the cell · 2007Article
- Canonical interaction of cyclin G associated kinase with adaptor protein 1 regulates lysosomal enzyme sorting.Molecular biology of the cell · 2007Article
- Ent3p and Ent5p exhibit cargo-specific functions in trafficking proteins between the trans-Golgi network and the endosomes in yeast.Molecular biology of the cell · 2007Article
- High-content microscopy identifies new neurite outgrowth regulators.Molecular biology of the cell · 2007Article
- Maturation of the mammalian secretome.Genome biology · 2007Review
- Laa1p, a conserved AP-1 accessory protein important for AP-1 localization in yeast.Molecular biology of the cell · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A novel peripheral membrane protein (2c18) that interacts directly with the gamma 'ear' domain of the adaptor protein complex 1 (AP-1) in vitro and in vivo is described. Ultrastructural analysis demonstrates a colocalization of 2c18 and gamma1-adaptin at the trans-Golgi network (TGN) and on vesicular profiles. Overexpression of 2c18 increases the fraction of membrane-bound gamma1-adaptin and inhibits its release from membranes in response to brefeldin A. Knockdown of 2c18 reduces the steady-state levels of gamma1-adaptin on membranes. Overexpression or downregulation of 2c18 leads to an increased secretion of the lysosomal hydrolase cathepsin D, which is sorted by the mannose-6-phosphate receptor at the TGN, which itself involves AP-1 function for trafficking between the TGN and endosomes. This suggests that the direct interaction of 2c18 and gamma1-adaptin is crucial for membrane association and thus the function of the AP-1 complex in living cells. We propose to name this protein gamma-BAR.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.