ArticleMedGenMed : Medscape general medicine2004
The effect of sildenafil citrate on uterine and clitoral arterial blood flow in postmenopausal women.
Article in MedGenMed : Medscape general medicine, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 22 citations in OpenAlex.
- Female Sexual Dysfunction: Is It a Treatable Disease?Current urology reports · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to determine the effect of sildenafil on the uterine circulation and clitoral artery blood flow in postmenopausal women using color Doppler sonography.
methodsThe study population consisted of 25 volunteer naturally postmenopausal women (mean age, 50.2 +/- 3.6 years). Color Doppler sonography was performed to measure the resistance and pulsatility indexes of the uterine arteries and peak systolic velocity, resistance, and pulsatility indexes of the clitoral arteries. One hour after administration of a single oral dose of 50 mg sildenafil citrate, the Doppler sonographic examination was repeated.
resultsAfter sildenafil administration, the mean resistance and pulsatility indexes of uterine artery were significantly lower (0.73 +/- 0.08 vs 0.80 +/- 0.07, P < .001 and 1.66 +/- 0.50 vs 2.08 +/- 0.52, P < .001, respectively) in comparison to baseline values, and the mean peak systolic velocity of clitoral artery was significantly higher (17.9 +/- 8.6 cm/sec vs 12.9 +/- 5.8 cm/sec, P < .001). Sildenafil did not cause any significant change in the mean resistance and pulsatility indexes of the clitoral artery (P = .683 and P = .714, respectively).
conclusionSildenafil improves the clitoral and uterine blood flow in healthy postmenopausal women without any erotic stimulus. Further studies are needed to determine whether there are roles for sildenafil therapy in postmenopausal women and evaluation of clitoral blood flow by Doppler sonography.
Indexed as
Identifiers
15775878PMC1480594W2295864849What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.