ArticleProceedings of the National Academy of Sciences of the United States of America2005
Defective B cell responses in the absence of SH2D1A.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 73 citations in OpenAlex.
- Article
- Characterization of Ly108-H1 Signaling Reveals Ly108-3 Expression and Additional Strain-Specific Differences in Lupus Prone Mice.International journal of molecular sciences · 2023Article
- Tfh Cells in Health and Immunity: Potential Targets for Systems Biology Approaches to Vaccination.International journal of molecular sciences · 2020Review
- Sex differences in neuro(auto)immunity and chronic sciatic nerve pain.Biology of sex differences · 2020Review
- Genes known to escape X chromosome inactivation predict co-morbid chronic musculoskeletal pain and posttraumatic stress symptom development in women following trauma exposure.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2019Article
- SLAMF6 in health and disease: Implications for therapeutic targeting.Clinical immunology (Orlando, Fla.) · 2019Review
- X-Linked Lymphoproliferative Disease Type 1: A Clinical and Molecular Perspective.Frontiers in immunology · 2018Review
- Follicular Helper T Cells are Essential for the Elimination of Plasmodium Infection.EBioMedicine · 2017Article
- SAP and Lessons Learned from a Primary Immunodeficiency.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Decreased SAP Expression in T Cells from Patients with Systemic Lupus Erythematosus Contributes to Early Signaling Abnormalities and Reduced IL-2 Production.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Responses to Microbial Challenges by SLAMF Receptors.Frontiers in immunology · 2016Review
- Staphylococcal Enterotoxin B (SEB) Induces Memory CD4 T Cell AnergyJournal of clinical & cellular immunology · 2015Article
- Negative Regulation of Humoral Immunity Due to Interplay between the SLAMF1, SLAMF5, and SLAMF6 Receptors.Frontiers in immunology · 2015Article
- Article
- SAP modulates B cell functions in a genetic background-dependent manner.Immunology letters · 2013Article
- SAP expression in invariant NKT cells is required for cognate help to support B-cell responses.Blood · 2012Article
- Biochemical and genetic evidence for a SAP-PKC-theta interaction contributing to IL-4 regulation.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- SLAM family receptors and the SLAM-associated protein (SAP) modulate T cell functions.Seminars in immunopathology · 2010Review
- Short telomeres are sufficient to cause the degenerative defects associated with aging.American journal of human genetics · 2009Article
- Follicular helper T cells are required for systemic autoimmunity.The Journal of experimental medicine · 2009Article
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Authors and funding
17 authors at 3 institutions in 1 country.
Funding
Abstract
More than half of patients with X-linked lympho-proliferative disease, which is caused by a defect in the intracellular adapter protein SH2D1A, suffer from an extreme susceptibility to Epstein-Barr virus. One-third of these patients, however, develop dysgammaglobulenemia without an episode of severe mononucleosis. Here we show that in SH2D1A(-/-) mice, both primary and secondary responses of all Ig subclasses are severely impaired in response to specific antigens. Because germinal centers were absent in SH2D1A(-/-) mice upon primary immunization, and because SH2D1A was detectable in wt germinal center B cells, we examined whether SH2D1A(-/-) B cell functions were impaired. Using the adoptive cotransfer of B lymphocytes from hapten-primed SH2D1A(-/-) mice with CD4(+) T cells from primed wt mice into irradiated wt mice provided evidence that signal transduction events controlled by SH2D1A are essential for B cell activities resulting in antigen specific IgG production. Defects in naive SH2D1A(-/-) B cells became evident upon cotransfer with non-primed wt CD4(+) cells into Rag2(-/-) recipients. Thus, both defective T and B cells exist in the absence of SH2D1A, which may explain the progressive dysgammaglobulinemia in a subset of X-linked lympho-proliferative disease patients without involvement of Epstein-Barr virus.
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