ReviewThe Journal of physiology2005
Investigating the causes of low birth weight in contrasting ovine paradigms.
Review in The Journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- Multicohort analysis unveils axon guidance pathways linking small for gestational age to spirometric restriction.Nature communications · 2026Article
- Impact of paternal high energy diets on semen quality and embryo development in cattle.Reproduction & fertility · 2025Review
- Intrauterine fetal growth restriction in sheep leads to sexually dimorphic programming of Preadipocytes' differentiation potential.Physiological reports · 2024Article
- Article
- Impact of Chorionic Somatomammotropin In Vivo RNA Interference Phenotype on Uteroplacental Expression of the IGF Axis.Life (Basel, Switzerland) · 2023Article
- Dousing the flame: reviewing the mechanisms of inflammatory programming during stress-induced intrauterine growth restriction and the potential for ω-3 polyunsaturated fatty acid intervention.Frontiers in physiology · 2023Review
- Identification of cow-level risk factors and associations of selected blood macro-minerals at parturition with dystocia and stillbirth in Holstein dairy cows.Scientific reports · 2022Article
- Differentially expressed genes in cotyledon of ewes fed mycotoxins.BMC genomics · 2020Article
- Identification of Pathways Associated with Placental Adaptation to Maternal Nutrient Restriction in Sheep.Genes · 2020Article
- ASAS-SSR Triennnial Reproduction Symposium: Looking Back and Moving Forward-How Reproductive Physiology has Evolved: Fetal origins of impaired muscle growth and metabolic dysfunction: Lessons from the heat-stressed pregnant ewe.Journal of animal science · 2018Review
- Adrenal Demedullation and Oxygen Supplementation Independently Increase Glucose-Stimulated Insulin Concentrations in Fetal Sheep With Intrauterine Growth Restriction.Endocrinology · 2016Article
- Increased fetal myocardial sensitivity to insulin-stimulated glucose metabolism during ovine fetal growth restriction.Experimental biology and medicine (Maywood, N.J.) · 2016Article
- Impacts of Maternal Nutrition on Vascularity of Nutrient Transferring Tissues during Gestation and Lactation.Nutrients · 2015Review
- Investigating developmental cardiovascular biomechanics and the origins of congenital heart defects.Frontiers in physiology · 2014Review
- Reductions in insulin concentrations and β-cell mass precede growth restriction in sheep fetuses with placental insufficiency.American journal of physiology. Endocrinology and metabolism · 2013Article
- A physiological increase in insulin suppresses gluconeogenic gene activation in fetal sheep with sustained hypoglycemia.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Article
- Effects of elevated ambient temperature on reproductive outcomes and offspring growth depend on exposure time.TheScientificWorldJournal · 2012Article
- The intrauterine growth restriction phenotype: fetal adaptations and potential implications for later life insulin resistance and diabetes.Seminars in reproductive medicine · 2011Review
- Catecholamines mediate multiple fetal adaptations during placental insufficiency that contribute to intrauterine growth restriction: lessons from hyperthermic sheep.Journal of pregnancy · 2011Review
- No juvenile arterial hypertension in sheep multiples despite reduced nephron numbers.Pediatric nephrology (Berlin, Germany) · 2010Article
Corrections and comments
- Commented on by
Authors and funding
5 authors.
Funding
Abstract
Intrauterine growth restriction (IUGR) still accounts for a large incidence of infant mortality and morbidity worldwide. Many of the circulatory and transport properties of the sheep placenta are similar to those of the human placenta and as such, the pregnant sheep offers an excellent model in which to study the development of IUGR. Two natural models of ovine IUGR are those of hyperthermic exposure during pregnancy, and adolescent overfeeding, also during pregnancy. Both models yield significantly reduced placental weights and an asymmetrically growth-restricted fetus, and display altered maternal hormone concentrations, indicative of an impaired trophoblast capacity. Additionally, impaired placental angiogenesis and uteroplacental blood flow appears to be an early defect in both the hyperthermic and adolescent paradigms. The effects of these alterations in placental functional development appear to be irreversible. IUGR fetuses are both hypoxic and hypoglycaemic, and have reduced insulin and insulin-like growth factor-1 (IGF-1), and elevated concentrations of lactate. However, fetal utilization of oxygen and glucose, on a weight basis, remain constant compared with control pregnancies. Maintained utilization of these substrates, in a substrate-deficient environment, suggests increased sensitivities to metabolic signals, which may play a role in the development of metabolic diseases in later adult life.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.