Trial reportPsychopharmacology2005
Individual differences in threat sensitivity predict serotonergic modulation of amygdala response to fearful faces.
Trial report in Psychopharmacology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 2 syntheses or guidelines pooled it, 162 citations in OpenAlex.
- Functional atlas of emotional faces processing: a voxel-based meta-analysis of 105 functional magnetic resonance imaging studies.Journal of psychiatry & neuroscience : JPN · 2009Pooled it
- Neuroimaging and electrophysiological studies of the effects of acute tryptophan depletion: a systematic review of the literature.Psychopharmacology · 2006Pooled it
- Oxytocinergic Modulation of Stress-Associated Amygdala-Hippocampus Pathways in Humans Is Mediated by Serotonergic Mechanisms.The international journal of neuropsychopharmacology · 2022Trial
- Effects of acute treatment with a tryptophan-rich protein hydrolysate on plasma amino acids, mood and emotional functioning in older women.Psychopharmacology · 2014Trial
- Trial
- Effects of acute tryptophan depletion on prefrontal-amygdala connectivity while viewing facial signals of aggression.Biological psychiatry · 2012Trial
- Time series fMRI measures detect changes in pontine raphé following acute tryptophan depletion.Psychiatry research · 2011Trial
- Fluoxetine treatment of alcoholic perpetrators of domestic violence: a 12-week, double-blind, randomized, placebo-controlled intervention study.The Journal of clinical psychiatry · 2011Trial
- The effect of acute tryptophan depletion on emotional distraction and subsequent memory.Social cognitive and affective neuroscience · 2009Trial
- Acute tryptophan depletion evokes negative mood in healthy females who have previously experienced concurrent negative mood and tryptophan depletion.Psychopharmacology · 2009Trial
- The effect of acute tryptophan depletion on the neural correlates of emotional processing in healthy volunteers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2008Trial
- Impaired recognition of fear facial expressions in 5-HTTLPR S-polymorphism carriers following tryptophan depletion.Psychopharmacology · 2006Trial
- The effect of acute tryptophan depletion on the BOLD response during performance monitoring and response inhibition in healthy male volunteers.Psychopharmacology · 2006Trial
- Evolutionary Mismatch, Stress, and Competition: Making Sense of Psychosocial Problems in the Polycrisis Era.Behavioral sciences (Basel, Switzerland) · 2026Review
- State and trait serotonin variations interact to shape the intrinsic connectivity and gradient architecture of the brain - a combined TPH2 genetics and tryptophan depletion study in men.Psychopharmacology · 2026Article
- Predicting the onset of internalizing disorders in early adolescence using deep learning optimized with AI.Frontiers in psychiatry · 2025Article
- Personality Functioning in Current Epilepsy Patients and People Recovered from Epilepsy.Reports (MDPI) · 2023Article
- Associations between anxiety, centromedial amygdala volume, and complex verbal fluency in middle-aged to older adults.Journal of clinical and experimental neuropsychology · 2022Article
- Variation of Genes Encoding Tryptophan Catabolites Pathway Enzymes in Stroke.Journal of clinical medicine · 2019Article
- Threat sensitivity is associated with the healthcare source used most often: doctor's office, emergency room, or none at all.Heliyon · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
rationaleIn this study we used functional magnetic resonance imaging (fMRI) to examine the effects of acute tryptophan depletion (ATD), a well-recognised method for inducing transient cerebral serotonin depletion, on brain activation to fearful faces.
objectivesWe predicted that ATD would increase the responsiveness of the amygdala to fearful faces as a function of individual variation in threat sensitivity.
methodsTwelve healthy male volunteers received a tryptophan depleting drink or a tryptophan balancing amino acid drink (placebo) in a double-blind crossover design. Five hours after drink ingestion participants were scanned whilst viewing fearful, happy and neutral faces.
resultsConsistent with previous findings, fearful faces induced significant signal change in the bilateral amygdala/hippocampus as well as the fusiform face area and the right dorsolateral prefrontal cortex. Furthermore, ATD modulated amygdala/hippocampus activation in response to fearful relative to happy faces as a function of self-reported threat sensitivity (as measured with the Behavioral Inhibition Scale; Carver CS, White TL (1994) Behavioral inhibition, behavioral activation, and affective responses to impending reward and punishment: the BIS/BAS scales. J Pers Soc Psychol 67:319-333).
conclusionThe data support the hypothesis that individual variation in threat sensitivity interacts with manipulation of 5-HT function to bias the processing of amygdala-dependent threat-relevant stimuli.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.