ArticleMolecular biology of the cell2005
Cell cycle-regulated, microtubule-independent organelle division in Cyanidioschyzon merolae.
Article in Molecular biology of the cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 61 citations in OpenAlex.
- Plant organelle division orchestrated by the mosaic machinery of endosymbiotic relics and eukaryotic host factors.Plant physiology · 2026Review
- Conserved DNA architect couples chloroplast development to cell cycle in developing cotyledons.Nature plants · 2026Article
- A fusion protein of polyphosphate kinase 1 (PPK1) and a Nudix hydrolase is involved in inorganic polyphosphate accumulation in the unicellular red alga Cyanidioschyzon merolae.Plant molecular biology · 2024Article
- Development of a rapamycin-inducible protein-knockdown system in the unicellular red alga Cyanidioschyzon merolae.Plant physiology · 2024Article
- How Light Modulates the Growth ofCells · 2023Article
- Biochemical Properties of β-Amylase from Red Algae and Improvement of Its Thermostability through Immobilization.ACS omega · 2022Article
- Article
- Relationship between Cell Cycle and Diel Transcriptomic Changes in Metabolism in a Unicellular Red Alga.Plant physiology · 2020Article
- Article
- Dynamics of the nucleoside diphosphate kinase protein DYNAMO2 correlates with the changes in the global GTP level during the cell cycle of Cyanidioschyzon merolae.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2019Article
- Onsite GTP fuelling via DYNAMO1 drives division of mitochondria and peroxisomes.Nature communications · 2018Article
- Glycosyltransferase MDR1 assembles a dividing ring for mitochondrial proliferation comprising polyglucan nanofilaments.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- RNA-seq analysis of the transcriptional response to blue and red light in the extremophilic red alga, Cyanidioschyzon merolae.Functional & integrative genomics · 2016Article
- Spatiotemporal dynamics of condensins I and II: evolutionary insights from the primitive red alga Cyanidioschyzon merolae.Molecular biology of the cell · 2013Article
- Golgi inheritance in the primitive red alga, Cyanidioschyzon merolae.Protoplasma · 2013Article
- Single-membrane-bounded peroxisome division revealed by isolation of dynamin-based machinery.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Mitotic inheritance of endoplasmic reticulum in the primitive red alga Cyanidioschyzon merolae.Protoplasma · 2012Article
- Division of cell nuclei, mitochondria, plastids, and microbodies mediated by mitotic spindle poles in the primitive red alga Cyanidioschyzon merolae.Protoplasma · 2010Article
- Mechanisms of organelle division and inheritance and their implications regarding the origin of eukaryotic cells.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2010Review
- Transient gene suppression in a red alga, Cyanidioschyzon merolae 10D.Protoplasma · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitochondrial and chloroplast division controls the number and morphology of organelles, but how cells regulate organelle division remains to be clarified. Here, we show that each step of mitochondrial and chloroplast division is closely associated with the cell cycle in Cyanidioschyzon merolae. Electron microscopy revealed direct associations between the spindle pole bodies and mitochondria, suggesting that mitochondrial distribution is physically coupled with mitosis. Interconnected organelles were fractionated under microtubule-stabilizing condition. Immunoblotting analysis revealed that the protein levels required for organelle division increased before microtubule changes upon cell division, indicating that regulation of protein expression for organelle division is distinct from that of cytokinesis. At the mitochondrial division site, dynamin stuck to one of the divided mitochondria and was spatially associated with the tip of a microtubule stretching from the other one. Inhibition of microtubule organization, proteasome activity or DNA synthesis, respectively, induced arrested cells with divided but shrunk mitochondria, with divided and segregated mitochondria, or with incomplete mitochondrial division restrained at the final severance, and repetitive chloroplast division. The results indicated that mitochondrial morphology and segregation but not division depend on microtubules and implied that the division processes of the two organelles are regulated at distinct checkpoints.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.