ReviewPharmaceutical research2005
Polyethylene glycol-conjugated copolymers for plasmid DNA delivery.
Review in Pharmaceutical research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed.
- Design of Folate-Containing Liposomal Nucleic Acid Delivery Systems for Antitumor Therapy.Pharmaceutics · 2023Review
- Isolongifolene-loaded chitosan nanoparticles synthesis and characterization for cancer treatment.Scientific reports · 2022Article
- Recent Trends in the Preparation of Nano-Starch Particles.Molecules (Basel, Switzerland) · 2022Review
- Review
- Delivery strategies for CRISPR/Cas genome editing tool for retinal dystrophies: challenges and opportunities.Asian journal of pharmaceutical sciences · 2022Review
- Preparation and Characterization of a Liver Targeted, Poly(amidoamine) Based, Gene Delivery System.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Emerging strategies in reprogramming and enhancing the fate of mesenchymal stem cells for bone and cartilage tissue engineering.Journal of controlled release : official journal of the Controlled Release Society · 2021Review
- Lactoferrin, a unique molecule with diverse therapeutical and nanotechnological applications.International journal of biological macromolecules · 2020Review
- Stable Retinoid Analogue Targeted Dual pH-Sensitive Smart Lipid ECO/pDNA Nanoparticles for Specific Gene Delivery in the Retinal Pigment Epithelium.ACS applied bio materials · 2020Article
- Recent Advances in the Development of Bio-Reducible Polymers for Efficient Cancer Gene Delivery Systems.Cancer medicine journal · 2019Article
- Recent advances in the development of gene delivery systems.Biomaterials research · 2019Review
- Engineered atherosclerosis-specific zinc ferrite nanocomplex-based MRI contrast agents.Journal of nanobiotechnology · 2016Article
- Non-covalent complexes of folic acid and oleic acid conjugated polyethylenimine: An efficient vehicle for antisense oligonucleotide delivery.Colloids and surfaces. B, Biointerfaces · 2015Article
- Combination of Nanoparticle-Delivered siRNA for Astrocyte Elevated Gene-1 (AEG-1) and All-trans Retinoic Acid (ATRA): An Effective Therapeutic Strategy for Hepatocellular Carcinoma (HCC).Bioconjugate chemistry · 2015Article
- Peptide GE11-Polyethylene Glycol-Polyethylenimine for targeted gene delivery in laryngeal cancer.Medical oncology (Northwood, London, England) · 2015Article
- Simulation and Experimental Assembly of DNA-Graft Copolymer Micelles with Controlled Morphology.ACS biomaterials science & engineering · 2015Article
- Revisiting 30 years of biofunctionalization and surface chemistry of inorganic nanoparticles for nanomedicine.Frontiers in chemistry · 2014Review
- Delivery of Polymeric Nanoparticles to Target Vascular Diseases.Journal of biomolecular research & therapeutics · 2014Article
- Polyethylene glycolated PAMAM dendrimers-Efavirenz conjugates.International journal of pharmaceutical investigation · 2014Article
- Dendrimers for siRNA Delivery.Pharmaceuticals (Basel, Switzerland) · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polymeric gene delivery systems have been developed as an alternative for viral gene delivery systems to overcome the problems in the use of viral gene carriers. Polymeric carriers have many advantages as gene carriers such as low cytotoxicity, low immunogenicity, moderate transfection efficiency, no size-limit, low cost, and reproducibility. In the efforts to develop safe and efficient polymeric gene carriers, polyethylene glycol (PEG) has widely been used because of its excellent characteristics. PEG-conjugated copolymers have advantages for gene delivery: (1) The PEG-conjugated copolymers show low cytotoxicity to cells in vitro and in vivo, (2) PEG increases water-solubility of the polymer/DNA complex, (3) PEG reduces the interaction of the polymer/DNA complex with serum proteins and increases circulation time of the complex, 4) PEG can be used as a spacer between a targeting ligand and a cationic polymer. A targeting ligand at the end of a PEG chain is not disturbed by the interaction of a cationic polymer with plasmid DNA, and the PEG spacer increases the accessibility of the ligand to its receptor. In this review, PEG copolymers as gene carriers are introduced, and their characteristics are discussed.
Indexed as
Identifiers
15771224What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.