ArticleWorld journal of gastroenterology2005
Immunocytochemical detection of HoxD9 and Pbx1 homeodomain protein expression in Chinese esophageal squamous cell carcinomas.
Article in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- HOXD9/miR-451a/PSMB8 axis is implicated in the regulation of cell proliferation and metastasis via PI3K/AKT signaling pathway in human anaplastic thyroid carcinoma.Journal of translational medicine · 2023Article
- Homeobox D9 drives the malignant phenotypes and enhances the Programmed death ligand-1 expression in non-small cell lung cancer cells via binding to Angiopoietin-2 promoter.World journal of surgical oncology · 2023Article
- Increased Expression of the RBPMS Splice Variants Inhibits Cell Proliferation in Ovarian Cancer Cells.International journal of molecular sciences · 2022Article
- PBX1 Increases the Radiosensitivity of Oesophageal Squamous Cancer by Targeting of STAT3.Pathology oncology research : POR · 2020Article
- HOXD9 promote epithelial-mesenchymal transition and metastasis in colorectal carcinoma.Cancer medicine · 2020Article
- HOXD9 Activates the TGF-β/Smad Signaling Pathway to Promote Gastric Cancer.OncoTargets and therapy · 2020Article
- HOXD9 promotes the growth, invasion and metastasis of gastric cancer cells by transcriptional activation of RUFY3.Journal of experimental & clinical cancer research : CR · 2019Article
- TGFβ receptor 1: an immune susceptibility gene in HPV-associated cancer.Cancer research · 2014Article
- None-endoscopic Screening for Esophageal Squamous Cell Carcinoma- A Review.Middle East journal of digestive diseases · 2012Review
- PBX1 genomic pioneer function drives ERα signaling underlying progression in breast cancer.PLoS genetics · 2011Article
- Functional analysis of HOXD9 in human gliomas and glioma cancer stem cells.Molecular cancer · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the expression pattern of two novel oncofetal antigens, the HoxD9 and Pbx1 homeoproteins in esophageal squamous cell carcinomas (ESCCs) to determine what role they would play in the carcinogenesis of ESCC.
methodsWe obtained tissue samples of ESCC from 56 patients who underwent esophagectomy but not preoperative chemotherapy or radiotherapy. The diagnosis of ESCC was established and confirmed by staff pathologists. We used a highly sensitive, indirect, immunocytochemical method to detect HoxD9 and PbX1 proteins. We qualitatively and quantitatively evaluated cells that exhibited and staining using a light microscope.
resultsIn all observed carcinoma tissue samples, more than 60% of neoplastic cells stained lightly or strongly for HoxD9, and more than 50% of neoplastic cells stained lightly or strongly for Pbx1.
conclusionOur data suggest that HoxD9 and Pbx1 are inappropriately expressed in most human esophageal squamous cell carcinoma. Understanding the role of Hox genes in esophageal epithelial cell carcinogenesis may not only augment early detection but also offer new avenues for treatment of this disease.
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