Trial reportEuropean journal of clinical pharmacology1992
Analgesic efficacy of immediate and sustained release paracetamol and plasma concentration of paracetamol. Double blind, placebo-controlled evaluation using painful laser stimulation.
Trial report in European journal of clinical pharmacology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- A new laser pain threshold model detects a faster onset of action from a liquid formulation of 1 g paracetamol than an equivalent tablet formulation.British journal of clinical pharmacology · 2002Trial
- Optimal Timing of Intravenous Acetaminophen Administration for Postoperative Analgesia.Anesthesia progress · 2022Article
- Modelling Tools to Characterize Acetaminophen Pharmacokinetics in the Pregnant Population.Pharmaceutics · 2021Review
- A Social Analgesic? Acetaminophen (Paracetamol) Reduces Positive Empathy.Frontiers in psychology · 2019Article
- Effects of analgesics and antidepressants on TREK-2 and TRESK currents.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2016Article
- Paracetamol: a focus for the general pediatrician.European journal of pediatrics · 2014Review
- The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings.Inflammopharmacology · 2013Review
- Assessing efficacy of non-opioid analgesics in experimental pain models in healthy volunteers: an updated review.British journal of clinical pharmacology · 2009Review
- The safety profile of sustained release paracetamol during therapeutic use and following overdose.Drug safety · 2005Review
- Intravenous paracetamol (propacetamol) pharmacokinetics in term and preterm neonates.European journal of clinical pharmacology · 2004Article
- A new high-absorption-rate Paracetamol 500-mg formulation: a comparative bioavailability study in healthy volunteers.Current therapeutic research, clinical and experimental · 2003Article
- Nonsteroidal anti-inflammatory agents in neonates.Paediatric drugs · 2003Review
- Paracetamol plasma and cerebrospinal fluid pharmacokinetics in children.British journal of clinical pharmacology · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The analgesic efficacy of single doses of immediate release paracetamol 500 mg and 1000 mg, sustained release paracetamol 2000 mg, and placebo was evaluated over a 12 h period in 10 healthy volunteers. The efficacy was related to the concurrent plasma concentrations of paracetamol. Experimental pain was induced by brief cutaneous application of argon laser pulses, and the analgesic effect was assessed as change in pricking pain threshold. Both 0.5 g and 1.0 g immediate release paracetamol had an analgesic effect superior to that of placebo from 1 to 5 h after administration. Peak analgesia was reached after 2 h. No difference was found in the analgesic effect of the two dosages. Sustained release paracetamol was not significantly superior to placebo at any time. The plasma concentration of paracetamol had peaked in the 1 h sample after of the immediate release tablet. The peak plasma concentration was reached 3-4 h after 2.0 g sustained release paracetamol. It is not known why the sustained release formulation did not produce any detectable analgesia. It is proposed, that the rate of increase in the plasma concentration of paracetamol might be important in the alleviation of acute (laser-induced) pain.
Indexed as
Identifiers
1577043What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.