ArticleWorld journal of surgery2005
Jaundice at presentation heralds advanced disease and poor prognosis in patients with ampullary carcinoma.
Article in World journal of surgery, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Prophylactic gastrojejunostomy for unresectable periampullary carcinoma.The Cochrane database of systematic reviews · 2013Pooled it
- Prediction of tumor recurrence after surgical resection of ampullary adenocarcinoma using magnetic resonance imaging.European radiology · 2024Article
- Prognostic Value of Myosteatosis and Creatinine-to-Cystatin C Ratio in Patients with Pancreatic Cancer Who Underwent Radical Surgery.Annals of surgical oncology · 2024Article
- Clinical impact of ampulla of Vater cancer subtype classification based on immunohistochemical staining.World journal of surgical oncology · 2024Article
- The coexistence of myosteatosis and the creatinine/cystatin C ratio are determinants of outcomes in cholangiocarcinoma patients undergoing curative surgery.Frontiers in oncology · 2024Article
- Article
- Pancreatoduodenectomy for Periampullary Tumors Presenting with Acute Pancreatitis.Gastroenterology research and practice · 2020Article
- Observational
- Preoperative platelet-lymphocyte ratio is an independent prognostic factor in ampullary carcinoma following pancreaticoduodenectomy.Oncology letters · 2018Article
- A nomogram prediction of postoperative surgical site infections in patients with perihilar cholangiocarcinoma.Medicine · 2017Observational
- Prognostic impact of immunohistochemical expression of CK7 and CK20 in curatively resected ampulla of Vater cancer.BMC gastroenterology · 2015Article
- Management of ampullary neoplasms: A tailored approach between endoscopy and surgery.World journal of gastroenterology · 2015Review
- Article
- Unresectable pancreatic adenocarcinoma: do we know who survives?HPB : the official journal of the International Hepato Pancreato Biliary Association · 2010Article
- Carcinoma of the papilla of Vater following treatment of pancreaticobiliary maljunction.World journal of gastroenterology · 2009Article
- Preoperative cholangitis independently increases in-hospital mortality after combined major hepatic and bile duct resection for hilar cholangiocarcinoma.Langenbeck's archives of surgery · 2009Article
- Recurrent pancreatitis caused by ampullary carcinoma and minor papilla adenoma in familial polyposis: report of a case.Surgery today · 2008Article
- Prognostic factors in gallbladder and biliary tract cancer.Medical oncology (Northwood, London, England) · 2007Article
- Carcinoma of the ampulla of Vater: factors influencing long-term survival of 127 patients with resection.World journal of surgery · 2007Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Jaundice is a common manifestation of ampullary carcinoma. The aim of this study was to evaluate the correlation between jaundice at initial presentation and the degree of tumor spread and to determine the prognostic significance of jaundice in patients with ampullary carcinoma. Fifty-nine patients who had undergone curative resection for ampullary carcinoma were analyzed retrospectively. Jaundice was defined as a total bilirubin serum concentration of > or = 3 mg/dl. The median follow-up time was 106 months. Jaundice was noted at the time of initial presentation in 43 (73%) patients. Jaundice at presentation correlated with lymph node metastasis (p < 0.0001), lymphatic vessel invasion (p < 0.0001), invasion into the pancreas (p = 0.0007), and vascular invasion (p = 0.0487). Pancreatic invasion was absent in patients without jaundice. Superior mesenteric nodal involvement was more frequent in patients with jaundice (15/43) than in those without (0/16) (p = 0.0062). The survival of patients with jaundice (median survival 48 months; cumulative 10-year survival rate 39%) was worse than for patients without jaundice (median survival time not available; cumulative 10-year survival rate 86%) (p = 0.0014). In conclusion, jaundice at presentation predicts advanced-stage ampullary carcinoma and a poor prognosis. Pancreatic invasion and superior mesenteric nodal involvement were not observed in nonjaundiced patients.
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