ArticleMediators of inflammation2005
Immunomodulatory effects of the Tityus serrulatus venom on murine macrophage functions in vitro.
Article in Mediators of inflammation, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Immunogenicity of two representative American consensus scorpion neurotoxins from the genera Tityus and Centruroides.PLoS neglected tropical diseases · 2026Article
- Effect ofMolecules (Basel, Switzerland) · 2025Article
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- Immunomodulatory effect ofThe journal of venomous animals and toxins including tropical diseases · 2024Article
- Purification and characterization of a novel immunoregulatory peptide fromFood science & nutrition · 2023Article
- Review
- TanP: A Multifunctional Anionic Peptide FromFrontiers in molecular biosciences · 2021Article
- Serotherapy against Voltage-Gated Sodium Channel-Targeting αToxins from Androctonus Scorpion Venom.Toxins · 2019Review
- EP80317 Restrains Inflammation and Mortality Caused by Scorpion Envenomation in Mice.Frontiers in pharmacology · 2019Article
- Differential effect of Androctonus australis hector venom components on macrophage KEuropean biophysics journal : EBJ · 2019Article
- Tb II-I, a Fraction Isolated fromToxins · 2018Article
- Immunomodulatory activity of Tityus serrulatus scorpion venom on human T lymphocytes.The journal of venomous animals and toxins including tropical diseases · 2015Article
- Neutralizing effects of Mimosa tenuiflora extracts against inflammation caused by Tityus serrulatus scorpion venom.BioMed research international · 2014Article
- Resistance of cervical adenocarcinoma cells (HeLa) to venom from the scorpion Centruroides limpidus limpidus.The journal of venomous animals and toxins including tropical diseases · 2013Article
- Scorpion peptides: potential use for new drug development.Journal of toxicology · 2013Article
- Prevention of disuse osteoporosis in rats by Cordyceps sinensis extract.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012Article
- Macrophage activation, phagocytosis and intracellular calcium oscillations induced by scorpion toxins from Tityus serrulatus.Clinical and experimental immunology · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tityus serrulatus scorpion venom (TSV) consists of a very complex mixture of molecules and demonstrates significant immunomodulatory activities capable of stimulating immune functions in vivo. The purpose of this study was to compare the crude TSV with fractionated toxins extracted from this venom in order to determine which toxin(s) presented immunomodulatory effects on peritoneal macrophages. TSV was fractionated using gel filtration chromatography resulting in 5 heterogeneous fractions. The effects of these different fractions were analysed in vitro using detection by means of cytokines, oxygen intermediate metabolites (H2O2), and nitric oxide (NO) in supernatants of peritoneal macrophages. Several functional bioassays were employed: tumor necrosis factor (TNF) activity was assayed by measuring its cytotoxic activity in L929 cells, and other cytokines were assayed by enzyme-linked immunosorbent assay, whereas NO levels were detected by Griess colorimetric reactions in culture supernatant of macrophages exposed to different fractions. In vitro studies revealed that all fractions studied here presented an increment in H2O2, NO , and cytokines levels. The more pronounced increments were observed in macrophage cultures exposed to fraction FII which demonstrated that (a) the highest levels of IL-1alpha, IL-beta, and TNF were observed after 12 hours and that (b) the maximum levels of IFN-gamma and NO were observed after 72 hours. Taken together, these data indicate that fractions have a differential immunomodulating effect on macrophage secretion, and that FII is a potent activator of TNF production of macrophages.
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