ArticleMediators of inflammation2004
Semiquantitative analysis of intrahepatic CC-chemokine mRNas in chronic hepatitis C.
Article in Mediators of inflammation, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 55 citations in OpenAlex.
- Cytokines Induced byBiomolecules · 2021Article
- Hepatitis C virus-induced CCL5 secretion from macrophages activates hepatic stellate cells.Hepatology (Baltimore, Md.) · 2017Article
- Serum levels of chemokines CCL4 and CCL5 in cirrhotic patients indicate the presence of hepatocellular carcinoma.British journal of cancer · 2015Article
- Maraviroc: a review of its use in HIV infection and beyond.Drug design, development and therapy · 2015Review
- Gene expression profiles of peripheral blood mononuclear cells in primary biliary cirrhosis.Clinical and experimental medicine · 2014Article
- Molecular detection of monocyte chemotactic protein-1 polymorphism in spontaneous bacterial peritonitis patients.World journal of gastroenterology · 2014Article
- Interference with oligomerization and glycosaminoglycan binding of the chemokine CCL5 improves experimental liver injury.PloS one · 2012Article
- Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice.The Journal of clinical investigation · 2010Article
- Hepatic steatosis causes induction of the chemokine RANTES in the absence of significant hepatic inflammation.International journal of clinical and experimental pathology · 2010Article
- The role of chemokines in the recruitment of lymphocytes to the liver.Digestive diseases (Basel, Switzerland) · 2010Review
- Differential expression of the CXCR3 ligands in chronic hepatitis C virus (HCV) infection and their modulation by HCV in vitro.Journal of virology · 2009Article
- Modulation of RANTES expression by HCV core protein in liver derived cell lines.BMC gastroenterology · 2007Article
- Differential expression of chemokines and their receptors in adult and neonatal macrophages infected with human or avian influenza viruses.The Journal of infectious diseases · 2006Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe mechanisms leading to hepatic injury in chronic hepatitis C virus (HCV) infection are only incompletely understood. Recent data propose a correlation of the intrahepatic expression of the CC chemokine RANTES and the degree of periportal and portal inflammatory liver damage.
aimHere, we have studied the intrahepatic mRNA levels of CC chemokines RANTES together with that of other members of this chemokine family (MIP-1beta, MCP-1, and MCP-2) in chronic hepatitis C as compared with healthy controls.
methodsLiver samples from 22 HCV-infected patients, nine individuals with primary biliary cirrhosis and from 12 normal controls were included into this study. Intrahepatic mRNA levels of CC chemokines RANTES, MIP-1beta, MCP-1, and MCP-2 were analyzed by a semi-quantitative reverse transcription/real-time polymerase chain reaction assay.
resultsIn chronic HCV infection, intrahepatic RANTES mRNA levels were significantly higher than in non-infected controls (7.2-fold, p < 0.001) or in the disease control group (2.8-fold, p < 0.001) and higher levels of RANTES mRNA levels were observed in livers with an advanced stage of liver cell injury (histologic activity index > or = 6), although this difference was not statistically significant (p = 0.08). In contrast, mRNA levels of MIP-1beta (p = 0.021) and MCP-1 (p = 0.021) were significantly lower in HCV liver samples while MCP-2 expression was similar in all groups analyzed.
conclusionThe data support the concept of chemokines as mediators of liver cell injury in chronic hepatitis C.
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