ArticleMolecular and cellular biology2005
TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- RNA-seq analysis of wild-type and mutated TBPL1 gene in breast cancer cells lines through CRISPR/Cas9 approach reveals novel molecular signatures.Scientific reports · 2025Article
- Case Report: Phenotypic heterogeneity within an NF1 family: assessment of the pathogenicity of aFrontiers in neuroscience · 2025Article
- Functional implications of paralog genes in polyglutamine spinocerebellar ataxias.Human genetics · 2023Review
- Top-down stepwise refinement identifies coding and noncoding RNA-associated epigenetic regulatory maps in malignant glioma.Journal of cellular and molecular medicine · 2022Article
- Deletion of the whole NF1 gene in a three-generation family with neurofibromatosis type 1.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Metalearning approach for leukemia informative genes prioritization.Journal of integrative bioinformatics · 2020Article
- The core-promoter factor TRF2 mediates a Fruitless action to masculinize neurobehavioral traits in Drosophila.Nature communications · 2017Article
- TBP-like protein (TLP) interferes with Taspase1-mediated processing of TFIIA and represses TATA box gene expression.Nucleic acids research · 2015Article
- Neurofibromatosis type 1: a single center's experience in Korea.Korean journal of pediatrics · 2014Article
- Activity of the upstream TATA-less promoter of the p21(Waf1/Cip1) gene depends on transcription factor IIA (TFIIA) in addition to TFIIA-reactive TBP-like protein.The FEBS journal · 2014Article
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- Transcription and Maturation of mRNA in Dinoflagellates.Microorganisms · 2013Review
- TATA-binding protein (TBP)-like protein is required for p53-dependent transcriptional activation of upstream promoter of p21Waf1/Cip1 gene.The Journal of biological chemistry · 2012Article
- TBP-related factors: a paradigm of diversity in transcription initiation.Cell & bioscience · 2011Article
- TATA-binding Protein (TBP)-like Protein Is Engaged in Etoposide-induced Apoptosis through Transcriptional Activation of Human TAp63 Gene.The Journal of biological chemistry · 2009Article
- TIPT2 and geminin interact with basal transcription factors to synergize in transcriptional regulation.BMC biochemistry · 2009Article
- The RNA polymerase II core promoter - the gateway to transcription.Current opinion in cell biology · 2008Review
- Variations in intracellular levels of TATA binding protein can affect specific genes by different mechanisms.Molecular and cellular biology · 2008Article
- dTrf2 is required for transcriptional and developmental responses to ecdysone during Drosophila metamorphosis.Developmental dynamics : an official publication of the American Association of Anatomists · 2007Article
- TBP paralogs accommodate metazoan- and vertebrate-specific developmental gene regulation.The EMBO journal · 2007Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
The lack of direct targets for TATA-binding protein (TBP)-like factors (TLFs) confounds the understanding of their role in gene expression. Here we report that human TLF (also called TBP-related factor 2 [TRF2]) activates a number of different genes, including the neurofibromatosis type 1 (NF1) gene. The overexpression of TLF increases the amount of NF1 mRNA in cells. In vivo, TLF binds to and upregulates transcription from a fragment of the NF1 promoter. In vitro, purified TLF-TFIIA binds directly to the same NF1 promoter fragment that is required for TLF responsiveness in cells. Furthermore, targeted deletion of TLF in mice reduces NF1 levels. In contrast, TLF inhibits transcription driven by a fragment from the TATA-containing c-fos promoter by sequestering TFIIA. TBP affects the NF1 and c-fos promoters in a manner reciprocal to that of TLF, stimulating the c-fos promoter and inhibiting NF1 transcription. We conclude that TLF is a functional regulator of transcription with targets distinct from those of TBP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.