ArticleMolecular and cellular biology2005
Nuclear export is evolutionarily conserved in CVC paired-like homeobox proteins and influences protein stability, transcriptional activation, and extracellular secretion.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
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- Disease-relevant signalling-pathways in head and neck cancer: Taspase1's proteolytic activity fine-tunes TFIIA function.Scientific reports · 2017Article
- Nucleoporin-Regulated MAP Kinase Signaling in Immunity to a Necrotrophic Fungal Pathogen.Plant physiology · 2016Article
- LocNES: a computational tool for locating classical NESs in CRM1 cargo proteins.Bioinformatics (Oxford, England) · 2015Article
- Nucleocytoplasmic shuttling and CRM1-dependent MHC class I peptide presentation of human cytomegalovirus pp65.Medical microbiology and immunology · 2012Article
- Human PAPS synthase isoforms are dynamically regulated enzymes with access to nucleus and cytoplasm.PloS one · 2012Article
- Article
- Karyopherins in nuclear transport of homeodomain proteins during development.Biochimica et biophysica acta · 2011Review
- Cell-based analysis of structure-function activity of threonine aspartase 1.The Journal of biological chemistry · 2011Article
- Bioassays to monitor Taspase1 function for the identification of pharmacogenetic inhibitors.PloS one · 2011Article
- hMSH5 is a nucleocytoplasmic shuttling protein whose stability depends on its subcellular localization.Nucleic acids research · 2010Article
- Repression of classical nuclear export by S-nitrosylation of CRM1.Journal of cell science · 2009Article
- The roles of multiple importins for nuclear import of murine aristaless-related homeobox protein.The Journal of biological chemistry · 2009Article
- Translocation Biosensors - Cellular System Integrators to Dissect CRM1-Dependent Nuclear Export by Chemicogenomics.Sensors (Basel, Switzerland) · 2009Article
- Negative regulation of Vsx1 by its paralog Chx10/Vsx2 is conserved in the vertebrate retina.Brain research · 2008Article
- The Survivin-Crm1 interaction is essential for chromosomal passenger complex localization and function.EMBO reports · 2006Article
- BMAL1 shuttling controls transactivation and degradation of the CLOCK/BMAL1 heterodimer.Molecular and cellular biology · 2006Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Homeodomain transcription factors control a variety of essential cell fate decisions during development. To understand the developmental regulation by these transcription factors, we describe here the molecular analysis of paired-like CVC homeodomain protein (PLC-HDP) trafficking. Complementary experimental approaches demonstrated that PLC-HDP family members are exported by the Crm1 pathway and contain an evolutionary conserved leucine-rich nuclear export signal. Importantly, inactivation of the nuclear export signal enhanced protein stability, resulting in increased transactivation of transfected reporters and decreased extracellular secretion. In addition, PLC-HDPs harbor a conserved active nuclear import signal that could also function as a protein transduction domain. In our study, we characterized PLC-HDPs as mobile nucleocytoplasmic shuttle proteins with the potential for unconventional secretion and intercellular transfer. Nucleocytoplasmic transport may thus represent a conserved control mechanism to fine-tune the transcriptional activity of PLC-HDPs prerequisite for regulating and maintaining the complex expression pattern during development.
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