ArticleProceedings of the National Academy of Sciences of the United States of America2005
Force production by depolymerizing microtubules: a theoretical study.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
50 citing papers in PubMed, 113 citations in OpenAlex.
- Ndc80 complex, a conserved coupler for kinetochore-microtubule motility, is a sliding molecular clutch.Science advances · 2025Article
- Microtubule dynamics are defined by conformations and stability of clustered protofilaments.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Responsive Supramolecular Polymers for Diagnosis and Treatment.International journal of molecular sciences · 2024Review
- Measuring and modeling forces generated by microtubules.Biophysical reviews · 2023Review
- Review
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- Controlling Exchange Pathways in Dynamic Supramolecular Polymers by Controlling Defects.ACS nano · 2021Article
- Mechanisms of microtubule dynamics and force generation examined with computational modeling and electron cryotomography.Nature communications · 2020Article
- Mechanics and kinetics of dynamic instability.eLife · 2020Article
- Mechanisms of Motor-Independent Membrane Remodeling Driven by Dynamic Microtubules.Current biology : CB · 2020Article
- Damage and Failure of Axonal Microtubule under Extreme High Strain Rate: An In-Silico Molecular Dynamics Study.Scientific reports · 2018Article
- Article
- Molecular photoswitches mediating the strain-driven disassembly of supramolecular tubules.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Deformation pattern in vibrating microtubule: Structural mechanics study based on an atomistic approach.Scientific reports · 2017Article
- Article
- Mechanism of Ska Recruitment by Ndc80 Complexes to Kinetochores.Developmental cell · 2017Article
- Microtubule-based force generation.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2017Review
- Electrostatic forces drive poleward chromosome motions at kinetochores.Cell division · 2016Article
- Molecular and Mechanical Causes of Microtubule Catastrophe and Aging.Biophysical journal · 2015Article
- Statistical mechanics provides novel insights into microtubule stability and mechanism of shrinkage.PLoS computational biology · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Chromosome movement during mitosis is powered in part by energy released through the depolymerization of kinetochore microtubules (MTs). Strong but indirect evidence suggests the existence of a specialized coupling between kinetochores and MT plus ends that enables this transduction of chemical energy into mechanical work. Analysis of this phenomenon is important for learning how energy is stored within the MT lattice, how it is transduced, and how efficient the process can be, given coupling devices of different designs. Here we use a recently developed molecular-mechanical model of MTs to examine the mechanism of disassembly dependent force generation. Our approach is based on changes in tubulin dimer conformation that occur during MT disassembly. We find that all of the energy of polymerization-associated GTP hydrolysis can be stored as deformations of the longitudinal bonds between tubulin dimers, and its optimal use does not require the weakening of lateral bonds between dimers. Maximum utilization of this stored energy and, hence, the generation of the strongest possible force, is achieved by a protofilament power-stroke mechanism, so long as the coupling device does not restrict full dissociation of the lateral bonds between tubulin dimers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.